Cefranov 500 mg (Capsule)

Unit Price: ৳ 12.50 (24's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Cephradine
Company Novus pharmaceuticals ltd
Also available as
Cefranov 125 mg suspension

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process of cell wall of bacteria
  • Cell lysis due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosage adjustment in renal impairment
  • Maximum daily dosage of 4 gm

Interaction

  • Increased risk of kidney damage with concomitant use of nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood disorders
  • Fever and serum sickness like reactions
  • Abdominal pain
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Caution in lactating mothers
  • Excretion in breast milk
  • Safety in pregnancy not established
  • Potential dizziness

Precautions & Warnings

  • Possible superinfection due to prolonged use
  • Risk of cross-sensitivity between beta-lactam antibiotics
  • Positive Coombs’ test result
  • False positive urine glucose result
  • Lactose content precautions

Use in Special Populations

  • Recommended doses for renal impairment and haemodialysis
  • Higher doses for chronic or severe infections
  • Continued treatment for persistent infections

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, diarrhoea
  • Supportive treatment
  • Gastric lavage if necessary

Therapeutic Class

  • First generation cephalosporins

Storage Conditions

  • Fresh preparation of Suspension
  • Reconstituted Suspension use within 7-14 days
  • Injection solutions use within 2 hours at room temperature
  • Solutions retain potency for 12 hours at 5°C
  • Variations in color of reconstituted solutions
  • Dispensing only on prescription of a registered physician

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