Cephradex DS 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.00

Medicine Details

Category Details
Generic Cephradine
Company Marker pharma ltd
Also available as

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Sinusitis
  • Pharyngitis
  • Tonsillitis
  • Laryngo-tracheo bronchitis
  • Otitis media
  • Lower respiratory tract infections
  • Bronchitis
  • Lobar pneumonia
  • Bronchopneumonia
  • Urinary tract infections
  • Cystitis
  • Urethritis
  • Pyelonephritis
  • Skin and soft tissue infections
  • Abscess
  • Cellulitis
  • Furunculosis
  • Impetigo

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in cell wall of bacteria

Dosage & Administration

  • For oral administration:
    • Doses for adults and children based on different types of infections
    • Dosage adjustment for elderly and patients with impaired renal or hepatic function
  • For injectable administration:
    • Usual doses for adults and children
    • Prophylactic dose for adults

Interaction

  • Nephrotoxic drug interaction
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Heartburn
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Blood disorders
  • Fever
  • Serum sickness like reactions
  • Anaphylaxis
  • Confusion
  • Sleep disturbances
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Animal studies have not demonstrated teratogenicity
  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution advised in lactating mothers

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Risk of cross-sensitivity with penicillins
  • Positive urine glucose result with certain tests
  • Dosage adjustment necessary in renal impairment
  • Contains lactose
  • Patients with rare hereditary problems should not take this medicine

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring required
  • Paediatric dosages should not exceed those specified for adults

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, and diarrhoea
  • Supportive treatment required
  • Gastric lavage may be necessary

Therapeutic Class

  • First generation cephalosporins

Storage Conditions

  • Suspension should be freshly prepared
  • Reconstituted Suspension should be used within specific timeframes
  • Injection solutions should be used within 2 hours when kept at room temperature
  • Solutions retain potency for 12 hours when stored at 5°C
  • Do not use past the date of expiry

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