Cephran 500 mg (Capsule)

Unit Price: ৳ 15.05 (4 x 7: ৳ 421.40)
Strip Price: ৳ 105.35

Medicine Details

Category Details
Generic Cephradine
Company Opsonin pharma ltd
Also available as
Cephran 125 mg suspension Cephran ds 250 mg suspension Cephran 125 mg pediatric drop Cephran 500 mg injection Cephran 1 gm injection

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Gram-positive microorganisms
  • Gram-negative microorganisms

Pharmacology

  • Bactericidal antibiotic
  • Broad spectrum antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process

Dosage & Administration

  • Oral administration for adults and children
  • Dosage adjustment for elderly and patients with impaired renal or hepatic function
  • Injectable administration for adults and children
  • Maximum daily dosage

Interaction

  • Concomitant use of nephrotoxic drugs
  • Enhanced risk of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Dizziness
  • Nausea
  • Vomiting
  • Blood disorders
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Teratogenicity not demonstrated in animal studies
  • Excretion in breast milk
  • Caution in lactating mothers
  • Caution about operating hazardous machinery

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Care in patients hypersensitive to penicillins
  • Positive result in Coombs’ testing
  • False positive urine glucose result
  • Dosage adjustment in renal impairment
  • Lactose content

Use in Special Populations

  • Dose recommendations for renal impairment
  • Dose recommendations for patients on chronic haemodialysis
  • Higher doses for chronic or severe infections
  • Treatment duration for rheumatic fever or glomerulonephritis prevention
  • Regular bacteriological and clinical monitoring
  • Paediatric dosages not to exceed adult dosages
  • Continued therapy for persistent infections

Overdose Effects

  • Non-specific symptoms
  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension shelf life
  • Injection solutions shelf life
  • Storage temperature impact on potency
  • Expiry date importance
  • Child-proof storage
  • Prescription requirement

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