Cephran 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 90.00

Medicine Details

Category Details
Generic Cephradine
Company Opsonin pharma ltd
Also available as
Cephran 500 mg capsule Cephran ds 250 mg suspension Cephran 125 mg pediatric drop Cephran 500 mg injection Cephran 1 gm injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Susceptibility to specific microorganisms

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacteria's cell wall
  • Main site of action is the cell wall of bacteria

Dosage & Administration

  • Oral administration for adults and children
  • Dosage recommendations for different types of infections
  • Dosage adjustment for elderly and patients with impaired renal or hepatic function
  • Injectable administration dosage for adults and children, including prophylactic dose

Interaction

  • Concomitant use with nephrotoxic drugs
  • Enhanced risk of renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Heartburn
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Investigations

Pregnancy & Lactation

  • Lack of demonstrated teratogenicity in animal studies
  • Excretion in breast milk
  • Caution in lactating mothers
  • Risk of causing dizziness

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Care with patients hypersensitive to penicillins
  • Positive Coombs' testing result
  • False positive urine glucose result
  • Dosage adjustment in renal impairment
  • Lactose content

Use in Special Populations

  • Dosing recommendations for patients with renal impairment
  • Additional dosing information for all patients
  • Caution with paediatric dosages
  • Possible need for continuing therapy in persistent infections
  • Transfer from intramuscular/intravenous therapy to oral treatment

Overdose Effects

  • Non-specific symptoms
  • Supportive treatment
  • Necessity of gastric lavage in case of large ingestion

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Fresh preparation of Cephran Suspension
  • Reconstituted Suspension usage duration
  • Cephran Injection solutions usage duration
  • Variation in color of reconstituted solutions
  • Expiration date
  • Instructions for keeping medicines away from children

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