Cephran DS 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 120.81

Medicine Details

Category Details
Generic Cephradine
Company Opsonin pharma ltd
Also available as
Cephran 500 mg capsule Cephran 125 mg suspension Cephran 125 mg pediatric drop Cephran 500 mg injection Cephran 1 gm injection

Title and Categories

  • Cephran DS
  • Medicine
  • Pharmaceutical

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in the cell wall of bacteria

Dosage & Administration

  • For oral administration
  • For injectable administration
  • Suitable doses for adults and children
  • Maximum daily dosage
  • Appropriate dose for elderly and patients with impaired renal or hepatic function

Interaction

  • Nephrotoxic drugs
  • Diuretics
  • Probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Heartburn
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Blood disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen
  • Elevation of serum creatinine
  • Elevation of alanine aminotransferase
  • Elevation of aspartate aminotransferase
  • Elevation of total bilirubin
  • Elevation of alkaline phosphatase

Pregnancy & Lactation

  • Safety not established in pregnancy
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Careful administration to patients hypersensitive to penicillins
  • Possibility of positive result in Coombs’ testing
  • Potential false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for patients with renal impairment and those on haemodialysis
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring
  • Paediatric dosages should not exceed those specified for adults

Overdose Effects

  • Non-specific symptoms including nausea, vomiting, diarrhea and gastric upsets
  • Supportive treatment

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepare Suspension
  • Limited shelf life of reconstituted Suspension and Injection solutions
  • Solutions retain potency when stored at specific temperatures
  • Dispensed only on the prescription of a registered physician

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