Dicef Forte 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 130.00

Medicine Details

Category Details
Generic Cephradine
Company Drug international ltd
Also available as
Dicef 250 mg capsule Dicef 500 mg capsule Dicef 125 mg suspension Dicef 125 mg pediatric drop

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Effective against Staphylococci
  • Effective against Streptococci
  • Effective against Escherichia coli
  • Effective against Klebsiella spp
  • Effective against Proteus mirabilis
  • Effective against Haemophilus influenza
  • Effective against Shigella spp
  • Effective against Salmonella spp
  • Effective against Neisseria spp

Pharmacology

  • Semisynthetic broad-spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacterial cell walls
  • Causes lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • Distribution in oral form for adults and children
  • Dosage varies for different types of infections
  • Recommended dosage for urinary tract infections
  • Recommended dosage for respiratory tract infections
  • Recommended dosage for skin and soft tissue infections
  • Maximum daily dosage of 4 gm
  • Dosage adjustment for elderly and patients with impaired renal or hepatic function
  • Distribution in injectable form for adults and children
  • Usual dose for adults and children
  • Prophylactic dose for adults
  • Dosage adjustments for severe infection and renal impairment

Interaction

  • Concomitant use of nephrotoxic drugs and Cefradine increases risk of kidney damage
  • Diuretics and probenecid enhance possibility of renal toxicity

Contraindications

  • Avoid use in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Possible skin reactions
  • Rare side effects: glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, abdominal pain, vaginitis, candida overgrowth, skin rashes, joint pains, edema, blood disorders, fever, psychiatric disorders, nervous system disorders, liver enzyme disturbances, reversible interstitial nephritis

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk, caution in lactating mothers
  • May cause dizziness, caution while operating hazardous machinery

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administer with care to patients hypersensitive to penicillins
  • May cause a false positive urine glucose result
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, avoid in patients with galactose intolerance or glucose-galactose malabsorption

Use in Special Populations

  • Recommended doses for renal impairment
  • Higher doses may be required for chronic or severe infections
  • Treatment duration for at least 2 to 3 days after symptoms have resolved or bacteria eradicated
  • Regular monitoring required for chronic urinary tract infections
  • Paediatric dosages not to exceed those specified for adults

Overdose Effects

  • Non-specific symptoms
  • Nausea, vomiting, diarrhoea, gastric upsets
  • Supportive treatment
  • Gastric lavage for large ingestions

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepare suspension
  • Reconstituted suspension should be used within 7 to 14 days
  • Injection solutions retain potency for 2 to 12 hours
  • Do not use later than the date of expiry
  • Dispense only on prescription of a registered physician
  • Keep all medicines out of the reach of children

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