Dicef 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 55.00

Medicine Details

Category Details
Generic Cephradine
Company Drug international ltd
Also available as
Dicef 250 mg capsule Dicef 500 mg capsule Dicef 125 mg suspension Dicef forte 250 mg suspension

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Effective against Staphylococci
  • Effective against Streptococci
  • Effective against Escherichia coli
  • Effective against Klebsiella
  • Effective against Proteus mirabilis
  • Indicated for abscess treatment
  • Indicated for cellulitis treatment
  • Indicated for furunculosis treatment
  • Indicated for impetigo treatment

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive microorganisms
  • Active against gram-negative microorganisms
  • Inhibits cross-linking process in bacterial cell wall
  • Causes lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults
  • Oral administration for children
  • Maximum daily dosage for children
  • Dosage for elderly patients
  • Injectable administration for adults
  • Dosage for injectable administration in children

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Heartburn
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Blood disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen and serum creatinine

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers
  • May cause dizziness

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Careful administration to patients hypersensitive to penicillins
  • May cause positive result in Coombs’ testing
  • May cause false positive urine glucose result
  • Dosage adjustment necessary in renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Additional Information for all patients
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring required
  • Paediatric dosages should not exceed those specified for adults

Overdose Effects

  • Non-specific symptoms
  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment required
  • Gastric lavage may be necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Dicef Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7 days at room temperature or within 14 days in a refrigerator
  • Dicef Injection solutions should be used within 2 hours at room temperature
  • Storage duration at 5°C
  • Disposal rules

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