Edin DS 250 mg/5 ml (Powder for Suspension)

Indications

• Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
• Upper respiratory tract infections
• Lower respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections

Pharmacology

• Semisynthetic broad spectrum bactericidal antibiotic
• Active against both gram-positive and gram-negative microorganisms
• Inhibits cross-linking process in bacterial cell wall
• Cell wall lysis due to external osmotic pressure

Dosage & Administration

• For oral administration in adults and children
• Dosage varies based on type and severity of infection
• Injectable administration dosage for adults and children
• Dosage adjustment for elderly and patients with impaired renal or hepatic function

Interaction

• Risk of kidney damage when used concomitantly with nephrotoxic drugs such as aminoglycosides
• Enhanced possibility of renal toxicity with diuretics and probenecid

Contraindications

• Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

• Gastro-intestinal disturbances
• Hypersensitivity phenomena
• Skin reactions
• Glossitis
• Heartburn
• Dizziness
• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Vaginitis
• Candida overgrowth
• Blood disorders
• Fever
• Serum sickness like reactions
• Anaphylaxis
• Confusion
• Sleep disturbances
• Hyperactivity
• Hypertonia
• Elevation of liver enzymes and bilirubin
• Reversible interstitial nephritis

Pregnancy & Lactation

• Safety in pregnancy not established
• Excreted in breast milk and should be used with caution in lactating mothers
• May cause dizziness, caution advised for operating hazardous machinery

Precautions & Warnings

• Prolonged use may result in superinfection
• Administered with care to patients hypersensitive to penicillins
• May cause a false positive urine glucose result
• Dosage adjustment necessary in renal impairment
• Contains lactose, caution for patients with rare hereditary problems of galactose intolerance or glucose-galactose malabsorption

Use in Special Populations

• Recommended doses for patients with renal impairment and on haemodialysis
• Higher doses may be required for chronic or severe infections
• Regular bacteriological and clinical monitoring required for chronic urinary tract infections

Overdose Effects

• Non-specific symptoms such as nausea, vomiting, diarrhoea, and gastric upsets
• Treatment is mainly supportive, gastric lavage may be necessary

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Freshly prepared Suspension should be used within 7-14 days based on storage temperature
• Injection solutions retain potency for 2-12 hours based on storage temperature
• Do not use after the expiry date
• Keep out of reach of children, dispensed only on prescription of a registered physician

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