Efrad 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 82.00

Medicine Details

Category Details
Generic Cephradine
Company Edruc limited
Also available as
Efrad 250 mg capsule Efrad 500 mg capsule

Indications

  • Treatment of infections caused by Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Susceptible microorganisms
  • Staphylococci
  • Streptococci
  • E.coli
  • Klebsiella spp
  • Proteus mirabilis
  • Haemophilus influenza
  • Shigella spp
  • Salmonella spp
  • Neisseria spp

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacterial cell wall
  • Susceptibility of penicillinase producing and nonproducing staphylococci to Cephradine

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosing specific to infection type and severity
  • Dosing adjustments for renal or hepatic impairment

Interaction

  • Nephrotoxic drug interaction
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Rare side effects include glossitis, heartburn, dizziness, etc.

Pregnancy & Lactation

  • No established safety in pregnancy
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Development of superinfection with prolonged use
  • Cross-sensitivity between beta-lactam antibiotics
  • Positive Coombs’ testing
  • False positive urine glucose result
  • Lactose content and rare hereditary problems

Use in Special Populations

  • Dosage adjustments for renal impairment
  • Higher doses for chronic or severe infections
  • Bacteriological and clinical monitoring for chronic urinary tract infections
  • Transfer to oral treatment from intramuscular/intravenous therapy
  • Paediatric dosages should not exceed those specified for adults

Overdose Effects

  • Non-specific symptoms include nausea, vomiting, and gastric upsets
  • Supportive treatment
  • Necessity of gastric lavage in case of large ingestion

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension usage duration
  • Injection solutions usage duration
  • Storage temperature impact on potency
  • Medicine storage safety precautions

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