Efrad 125 mg/5 ml (Powder for Suspension)
100 ml bottle: ৳ 82.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cephradine |
| Company | Edruc limited |
| Also available as |
Indications
- Treatment of infections caused by Gram-positive and Gram-negative bacteria
- Upper respiratory tract infections
- Lower respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
- Susceptible microorganisms
- Staphylococci
- Streptococci
- E.coli
- Klebsiella spp
- Proteus mirabilis
- Haemophilus influenza
- Shigella spp
- Salmonella spp
- Neisseria spp
Pharmacology
- Broad spectrum bactericidal antibiotic
- Active against gram-positive and gram-negative microorganisms
- Inhibition of cross-linking process in bacterial cell wall
- Susceptibility of penicillinase producing and nonproducing staphylococci to Cephradine
Dosage & Administration
- Oral administration for adults and children
- Injectable administration for adults and children
- Dosing specific to infection type and severity
- Dosing adjustments for renal or hepatic impairment
Interaction
- Nephrotoxic drug interaction
- Enhanced renal toxicity with diuretics and probenecid
Contraindications
- Hypersensitivity to cephalosporins
Side Effects
- Gastro-intestinal disturbances
- Hypersensitivity phenomena
- Skin reactions
- Rare side effects include glossitis, heartburn, dizziness, etc.
Pregnancy & Lactation
- No established safety in pregnancy
- Excretion in breast milk
- Caution in lactating mothers
Precautions & Warnings
- Development of superinfection with prolonged use
- Cross-sensitivity between beta-lactam antibiotics
- Positive Coombs’ testing
- False positive urine glucose result
- Lactose content and rare hereditary problems
Use in Special Populations
- Dosage adjustments for renal impairment
- Higher doses for chronic or severe infections
- Bacteriological and clinical monitoring for chronic urinary tract infections
- Transfer to oral treatment from intramuscular/intravenous therapy
- Paediatric dosages should not exceed those specified for adults
Overdose Effects
- Non-specific symptoms include nausea, vomiting, and gastric upsets
- Supportive treatment
- Necessity of gastric lavage in case of large ingestion
Therapeutic Class
- First generation Cephalosporins
Storage Conditions
- Freshly prepared suspension
- Reconstituted suspension usage duration
- Injection solutions usage duration
- Storage temperature impact on potency
- Medicine storage safety precautions