Extracef 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 62.00

Medicine Details

Category Details
Generic Cephradine
Company Aristopharma ltd
Also available as
Extracef 250 mg capsule Extracef 500 mg capsule Extracef 125 mg suspension Extracef ds 250 mg suspension

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Susceptible microorganisms: Staphylococci, Streptococci, E. coli, Klebsiella spp, Proteus mirabilis, etc.

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of bacterial cell wall cross-linking process

Dosage & Administration

  • Adult oral dosage for urinary tract infections: 500mg-1g four times daily
  • Adult oral dosage for respiratory tract infections: 250-500mg four times daily or 500mg-1g twice daily
  • Adult oral dosage for skin and soft tissue infections: 250-500mg four times daily or 500mg-1g twice daily
  • Total daily dose for children: 25-50mg/kg in divided doses
  • Maximum daily dosage: 4 gm
  • Elderly & impaired renal/hepatic function monitoring

Interaction

  • Potential risk of kidney damage with concomitant use of nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena including skin reactions, urticaria, and rashes
  • Rare effects: Glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, vaginitis, candida overgrowth, joint pains, oedema
  • Unknown: Blood disorders, fever, liver enzyme disturbances, reversible interstitial nephritis

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk, caution in lactating mothers
  • Dizziness caution for patients operating hazardous machinery

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Care with penicillin-hypersensitive patients
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result with certain test solutions
  • Dosage adjustment necessary in renal impairment
  • Containment of lactose, caution for patients with galactose intolerance

Use in Special Populations

  • Recommended doses for renal impairment and haemodialysis
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring for chronic urinary tract infections

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, and diarrhoea
  • Supportive treatment, gastric lavage for large ingestions

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Reconstituted Suspension: Use within 7-14 days
  • Injection solutions: Use within 2 hours at room temperature, 12 hours at 5°C
  • Potency unaffected by variation in color
  • Do not use after expiry date, keep out of reach of children

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