Extracef 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 62.00

Medicine Details

Category	Details
Generic	Cephradine
Company	Aristopharma ltd
Also available as	Extracef 250 mg capsule Extracef 500 mg capsule Extracef 125 mg suspension Extracef ds 250 mg suspension

Indications

Treatment of upper respiratory tract infections
Treatment of lower respiratory tract infections
Treatment of urinary tract infections
Treatment of skin and soft tissue infections
Susceptible microorganisms: Staphylococci, Streptococci, E. coli, Klebsiella spp, Proteus mirabilis, etc.

Pharmacology

Semisynthetic broad spectrum bactericidal antibiotic
Active against both gram-positive and gram-negative microorganisms
Inhibition of bacterial cell wall cross-linking process

Dosage & Administration

Adult oral dosage for urinary tract infections: 500mg-1g four times daily
Adult oral dosage for respiratory tract infections: 250-500mg four times daily or 500mg-1g twice daily
Adult oral dosage for skin and soft tissue infections: 250-500mg four times daily or 500mg-1g twice daily
Total daily dose for children: 25-50mg/kg in divided doses
Maximum daily dosage: 4 gm
Elderly & impaired renal/hepatic function monitoring

Interaction

Potential risk of kidney damage with concomitant use of nephrotoxic drugs
Enhanced renal toxicity with diuretics and probenecid

Contraindications

Hypersensitivity to cephalosporins

Side Effects

Gastro-intestinal disturbances
Hypersensitivity phenomena including skin reactions, urticaria, and rashes
Rare effects: Glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, vaginitis, candida overgrowth, joint pains, oedema
Unknown: Blood disorders, fever, liver enzyme disturbances, reversible interstitial nephritis

Pregnancy & Lactation

Safety in pregnancy not established
Excretion in breast milk, caution in lactating mothers
Dizziness caution for patients operating hazardous machinery

Precautions & Warnings

Prolonged use may result in superinfection
Care with penicillin-hypersensitive patients
Potential positive result in Coombs’ testing
Potential false positive urine glucose result with certain test solutions
Dosage adjustment necessary in renal impairment
Containment of lactose, caution for patients with galactose intolerance

Use in Special Populations

Recommended doses for renal impairment and haemodialysis
Higher doses for chronic or severe infections
Regular bacteriological and clinical monitoring for chronic urinary tract infections

Overdose Effects

Non-specific symptoms such as nausea, vomiting, and diarrhoea
Supportive treatment, gastric lavage for large ingestions

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Reconstituted Suspension: Use within 7-14 days
Injection solutions: Use within 2 hours at room temperature, 12 hours at 5°C
Potency unaffected by variation in color
Do not use after expiry date, keep out of reach of children

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