Gigacef 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 90.00

Medicine Details

Category Details
Generic Cephradine
Company Pacific pharmaceuticals ltd
Also available as
Gigacef 500 mg capsule Gigacef 125 mg pediatric drop

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Gram-positive bacteria susceptibility
  • Gram-negative bacteria susceptibility

Pharmacology

  • Broad-spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacteria cell wall
  • Cell wall lysis due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults and children
  • Dosage variations based on infection severity and site
  • Maximum daily dosage: 4 gm
  • Dosage adjustment for elderly and patients with renal or hepatic function impairment
  • Injectable administration for adults and children
  • Prophylactic dose for preoperative use

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Other rare reactions including glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, vaginitis, candida overgrowth, blood disorders, fever, serum sickness, anaphylaxis, confusion, liver enzyme disturbances, reversible interstitial nephritis

Pregnancy & Lactation

  • No established safety in pregnancy
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Cross-sensitivity risk to penicillins
  • Potential positive Coombs test result
  • Possible false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Lactose content caution for patients with certain hereditary conditions

Use in Special Populations

  • Dosage recommendations for patients with renal impairment and on haemodialysis
  • Requirement of higher doses for chronic or severe infections
  • Continued treatment for specific conditions
  • Monitoring required for urinary tract infections

Overdose Effects

  • Non-specific symptoms of nausea, vomiting, diarrhoea, and gastric upsets
  • Supportive treatment
  • Possible need for gastric lavage

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Usage timeframe for reconstituted suspension
  • Potency retention period for injection solutions
  • Variations in color of reconstituted solutions
  • Proper disposal after expiry
  • Storage guidelines for medicine safety

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