Intracef 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.00

Medicine Details

Category	Details
Generic	Cephradine
Company	Beximco pharmaceuticals ltd
Also available as	Intracef 250 mg capsule Intracef 500 mg capsule Intracef ds 250 mg suspension Intracef 125 mg pediatric drop

Indications

Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
Upper respiratory tract infections
Lower respiratory tract infections
Urinary tract infections
Skin and soft tissue infections

Pharmacology

Semisynthetic broad spectrum bactericidal antibiotic
Active against gram-positive and gram-negative microorganisms
Inhibits cross-linking process in bacterial cell wall
Cell wall contains peptidoglycan

Dosage & Administration

Oral administration for adults and children
Dosage based on site and severity of infection
Maximum daily dosage: 4 gm
Dosage adjustment necessary in renal impairment

Interaction

Concomitant use of nephrotoxic drugs may increase risk of kidney damage
Diuretics and probenecid enhance possibility of renal toxicity

Contraindications

Hypersensitivity to cephalosporins

Side Effects

Gastro-intestinal disturbances
Hypersensitivity phenomena
Skin reactions
Blood disorders
Immune system disorders
Psychiatric disorders
Nervous system disorders
Hepatobiliary disorders
Renal and urinary disorders
Elevation of blood urea nitrogen
Elevation of serum creatinine

Pregnancy & Lactation

Safety in pregnancy not established
Excreted in breast milk
Caution in lactating mothers
May cause dizziness

Precautions & Warnings

Prolonged use may result in superinfection
Administer with care to patients hypersensitive to penicillins
May cause a false positive urine glucose result
Contains lactose

Use in Special Populations

Doses recommended for patients not on haemodialysis
Doses recommended for patients on chronic, intermittent haemodialysis
Higher doses may be required for chronic or severe infections
Regular bacteriological and clinical monitoring required

Overdose Effects

Non-specific symptoms
Nausea
Vomiting
Diarrhoea
Gastric upsets
Gastric lavage necessary for large amount ingestion

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Freshly prepared suspension
Reconstituted Suspension should be used within 7-14 days
Solutions should be used within 2 hours at room temperature
Solutions retain potency for 12 hours when stored at 5°C
Keep out of reach of children
Dispensed only on prescription

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