Lebac 250 mg (Capsule)

Unit Price: ৳ 8.03 (3 x 6: ৳ 144.54)
Strip Price: ৳ 48.18

Medicine Details

Category Details
Generic Cephradine
Company Square pharmaceuticals plc
Also available as
Lebac 500 mg capsule Lebac 125 mg suspension Lebac forte 250 mg suspension Lebac 125 mg pediatric drop Lebac 500 mg injection

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Susceptibility to Gram-positive microorganisms
  • Susceptibility to Gram-negative microorganisms

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in cell wall of bacteria
  • Cell wall lysis due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults
  • Oral administration for children
  • Injectable administration for adults
  • Injectable administration for children
  • Dosage adjustment for elderly
  • Dosage adjustment for renal or hepatic function

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Heartburn
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Hypersensitivity reactions
  • Blood disorders
  • Fever
  • Serum sickness like reactions
  • Anaphylaxis
  • Confusion
  • Sleep disturbances
  • Nervousness
  • Headache
  • Liver enzyme disturbances
  • Transient hepatitis
  • Cholestatic jaundice
  • Reversible interstitial nephritis
  • Elevation of blood urea nitrogen
  • Elevation of serum creatinine
  • Elevation of alanine aminotransferase
  • Elevation of aspartate aminotransferase
  • Elevation of total bilirubin
  • Elevation of alkaline phosphatase

Pregnancy & Lactation

  • Teratogenicity not demonstrated in animal studies
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Risk of cross-sensitivity between beta-lactam antibiotics
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Lactose content

Use in Special Populations

  • Dosing recommendations for renal impairment
  • Dosing recommendations for haemodialysis
  • Higher doses for chronic or severe infections
  • Continued monitoring for chronic urinary tract infections

Overdose Effects

  • Non-specific symptoms
  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment
  • Gastric lavage

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension expiry
  • Injection solution expiry
  • Potency retention at 5°C
  • Dispensing on physician's prescription

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