Hipre 5 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of essential hypertension
- Treatment of angina pectoris
- Treatment of vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Influences myocardial cells
- Vasodilation effects
- Reduction of peripheral resistance
- Increased coronary blood flow
Dosage & Administration
- Usual dose of 5 mg once daily for hypertension
- Maximum dose of 10 mg once daily for hypertension
- Elderly patients with hepatic insufficiency may start on 2.5 mg once daily
- Dose of 5 to 10 mg for angina
- Lower dose for elderly and patients with hepatic insufficiency
Interaction
- Potentially hazardous interactions with p-blockers
- No interaction between Hipre and Digoxin
- No interaction between Hipre and Cimetidine
- No significant alteration of Warfarin effect by Hipre
- Food does not alter the rate or extent of absorption of Hipre
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnancy
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Paradoxical increase in ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- Adequate and well-controlled studies lacking
- Recommendation to discontinue nursing while Amlodipine is administered
Precautions & Warnings
- Precaution in patients with hepatic impairment
- Precaution during pregnancy and breastfeeding
Use in Special Populations
- Dosing recommendations for children with hypertension
- No known effect of amlodipine on blood pressure in patients under 6 years old
- Similar toleration in elderly and younger patients
- Normal dosage recommended for renal impairment
- Dosing caution for mild to moderate hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Active cardiovascular support required
- Potential use of vasoconstrictor
- Intravenous calcium gluconate may be beneficial
- Potential use of gastric lavage
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store in a cool & dry place
- Protected from light