Lebac Forte 250 mg/5 ml (Powder for Suspension)
100 ml bottle: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cephradine |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
- Upper respiratory tract infections
- Lower respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
Pharmacology
- Semisynthetic broad spectrum bactericidal antibiotic
- Active against gram-positive and gram-negative microorganisms
- Inhibition of cross-linking process in bacteria cell wall
- Bactericidal action due to cell lysis from external osmotic pressure
Dosage & Administration
- Oral and injectable administration
- Different doses for adults and children
- Dosage adjustment for elderly and patients with impaired renal or hepatic function
Interaction
- Increased risk of kidney damage with nephrotoxic drugs like aminoglycosides
- Enhanced renal toxicity with diuretics and probenecid
Contraindications
- Not to be used in patients with known or suspected hypersensitivity to cephalosporins
Side Effects
- Gastro-intestinal disturbances
- Hypersensitivity phenomena
- Possible skin reactions and glossitis
- Blood and lymphatic system disorders
- Immune system disorders
- Psychiatric disorders
- Nervous system disorders
- Hepatobiliary disorders
- Renal and urinary disorders
- Elevation of blood urea nitrogen
- Serum creatinine
- Liver enzyme disturbances
Pregnancy & Lactation
- Safety in pregnancy not established
- Excreted in breast milk
- Caution in lactating mothers
- Potential to cause dizziness
Precautions & Warnings
- Development of superinfection with prolonged use
- Administered with care to patients hypersensitive to penicillins
- Potential positive result in Coombs’ testing
- Potential false positive urine glucose result with certain tests
- Dosage adjustment in renal impairment
- Contains lactose and precautions for patients with rare hereditary problems
Use in Special Populations
- Recommended doses for patients with renal impairment and on haemodialysis
- Higher doses for chronic or severe infections
- Regular bacteriological and clinical monitoring for chronic urinary tract infections
- Paediatric dosages not to exceed those specified for adults
Overdose Effects
- Non-specific symptoms like nausea, vomiting, and diarrhoea
- Supportive treatment with gastric lavage if necessary
Therapeutic Class
- First generation Cephalosporins
Storage Conditions
- Freshly prepared suspension
- Limited shelf life of reconstituted suspension and injection solutions
- Variation in color of reconstituted solutions not affecting potency
- Dispensing only on prescription of a registered physician