Lebac Forte 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 140.00

Medicine Details

Category Details
Generic Cephradine
Company Square pharmaceuticals plc
Also available as
Lebac 250 mg capsule Lebac 500 mg capsule Lebac 125 mg suspension Lebac 125 mg pediatric drop Lebac 500 mg injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacteria cell wall
  • Bactericidal action due to cell lysis from external osmotic pressure

Dosage & Administration

  • Oral and injectable administration
  • Different doses for adults and children
  • Dosage adjustment for elderly and patients with impaired renal or hepatic function

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs like aminoglycosides
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Possible skin reactions and glossitis
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen
  • Serum creatinine
  • Liver enzyme disturbances

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers
  • Potential to cause dizziness

Precautions & Warnings

  • Development of superinfection with prolonged use
  • Administered with care to patients hypersensitive to penicillins
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result with certain tests
  • Dosage adjustment in renal impairment
  • Contains lactose and precautions for patients with rare hereditary problems

Use in Special Populations

  • Recommended doses for patients with renal impairment and on haemodialysis
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring for chronic urinary tract infections
  • Paediatric dosages not to exceed those specified for adults

Overdose Effects

  • Non-specific symptoms like nausea, vomiting, and diarrhoea
  • Supportive treatment with gastric lavage if necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Limited shelf life of reconstituted suspension and injection solutions
  • Variation in color of reconstituted solutions not affecting potency
  • Dispensing only on prescription of a registered physician

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