Lindex DS 250 mg/5 ml (Powder for Suspension)

Indications

• Treatment of upper respiratory tract infections
• Treatment of lower respiratory tract infections
• Treatment of urinary tract infections
• Treatment of skin and soft tissue infections
• Infections caused by sensitive Gram-positive bacteria
• Infections caused by sensitive Gram-negative bacteria

Pharmacology

• Semisynthetic broad spectrum bactericidal antibiotic
• Active against both gram-positive and gram-negative microorganisms
• Inhibition of cross-linking process in cell wall of bacteria

Dosage & Administration

• Adult dosage for urinary tract infections
• Adult dosage for respiratory tract infections
• Adult dosage for skin and soft tissue infections
• Children dosage for otitis media
• Maximum daily dosage
• Dosage adjustments in renal impairment

Interaction

• Nephrotoxic drug interactions
• Diuretic interactions
• Probenecid interactions

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

• Gastro-intestinal disturbances
• Hypersensitivity phenomena
• Skin reactions
• Blood and lymphatic system disorders
• Immune system disorders
• Psychiatric disorders
• Nervous system disorders
• Hepatobiliary disorders
• Renal and urinary disorders
• Elevation of blood urea nitrogen
• Elevation of serum creatinine
• Elevation of alanine aminotransferase
• Elevation of aspartate aminotransferase
• Elevation of total bilirubin
• Elevation of alkaline phosphatase

Pregnancy & Lactation

• Safety in pregnancy not established
• Excretion in breast milk

Precautions & Warnings

• Risk of superinfection
• Care in patients hypersensitive to penicillins
• Positive result in Coombs’ testing
• Potential false positive urine glucose result
• Lactose content caution

Use in Special Populations

• Recommended doses in renal impairment
• Dosing for patients on haemodialysis
• Higher doses for chronic or severe infections
• Duration of treatment for rheumatic fever or glomerulonephritis prevention
• Regular bacteriological and clinical monitoring
• Limitations on paediatric dosages

Overdose Effects

• Non-specific symptoms
• Supportive treatment
• Possibility of gastric lavage

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Freshly prepared suspension
• Reconstituted suspension shelf life
• Injection solutions shelf life
• Variation in color of reconstituted solutions
• Dispensing regulations

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