Medicef 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.00

Medicine Details

Category Details
Generic Cephradine
Company Medicon pharmaceuticals ltd
Also available as
Medicef 500 mg capsule

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections: bronchitis (acute and chronic), lobar pneumonia, bronchopneumonia
  • Urinary tract infections: cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo

Mode of Action

  • Broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in the cell wall of bacteria
  • Cell wall of sensitive organism contains peptidoglycan

Dosage & Administration

  • For oral administration in adults and children
  • For injectable administration in adults and children
  • Dosage adjustment necessary in renal impairment

Interaction

  • Increased risk of kidney damage with concomitant use of nephrotoxic drugs
  • Enhanced possibility of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions (rare)
  • Glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, abdominal pain
  • Fever, joint pains, oedema, blood disorders, liver enzyme disturbances

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administered with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result
  • Lactose content

Use in Special Populations

  • Renal impairment
  • Recommendations for patients on haemodialysis
  • Clinical monitoring required for chronic urinary tract infections

Overdose Effects

  • Non-specific symptoms
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension usage timeframe
  • Injection solutions usage timeframe
  • Retention of potency for reconstituted solutions
  • Keep out of reach of children

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