Multicef 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 60.00

Medicine Details

Category	Details
Generic	Cephradine
Company	Desh pharmaceuticals ltd
Also available as	Multicef 250 mg capsule Multicef 500 mg capsule Multicef 125 mg suspension

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Urinary tract infections
Skin and soft tissue infections

Pharmacology

Semisynthetic broad spectrum bactericidal antibiotic
Active against gram-positive and gram-negative microorganisms
Main site of action is the cell wall of bacteria

Dosage & Administration

For Oral Administration - Adults:
- Urinary tract infections: 500mg four times daily or 1g twice daily
- Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily
- Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily
For Oral Administration - Children:
- Total daily dose of 25 to 50mg/kg given in two or four equally divided doses
- Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly
- Maximum daily dosage: 4 gm
For Injectable Administration - Adult: Usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily
For Injectable Administration - Children: Dose is 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection

Interaction

The concomitant use of nephrotoxic drugs such as aminoglycosides with Cefradine may increase the risk of kidney damage

Contraindications

Cephradine should not be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

Gastro-intestinal disturbances
Hypersensitivity phenomena
Skin reactions
Glossitis
Heartburn
Dizziness
Nausea
Vomiting
Diarrhoea
Abdominal pain
Vaginitis
Candida overgrowth
Urticaria
Skin rashes
Joint pains
Oedema
Blood disorders
Fever
Anaphylaxis
Confusion
Liver enzyme disturbances
Transient hepatitis
Reversible interstitial nephritis
Elevation of blood urea nitrogen
Elevation of serum creatinine
Elevation of alanine aminotransferase
Elevation of aspartate aminotransferase
Elevation of total bilirubin
Elevation of alkaline phosphatase

Pregnancy & Lactation

Although animal studies have not demonstrated any teratogenicity, safety in pregnancy has not been established. Cephradine is excreted in breast milk and should be used with caution in lactating mothers

Precautions & Warnings

Prolonged use may result in the development of superinfection
Should be administered with care to patients hypersensitive to penicillins
May cause a positive result in Coombs' testing
May cause a false positive urine glucose result when Benedict's or Fehling's solutions or tablets such as Clinitest are used in the testing
Dosage adjustment is necessary in renal impairment
Contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine

Use in Special Populations

Renal Impairment: Doses recommended based on creatinine clearance
Pediatric Dosages: Should not exceed those specified for adults, regardless of severity of infection

Overdose Effects

Non-specific symptoms include nausea, vomiting, diarrhea and gastric upsets. Treatment is mainly supportive although gastric lavage will be necessary if a large amount has been ingested

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Suspension should be freshly prepared. Reconstituted Suspension should be used within 7 days if kept at room temperature or within 14 days if kept in a refrigerator. Injection solutions should be used within 2 hours when kept at room temperature. Solutions retain potency for 12 hours when stored at 5°C