Mycef 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 80.31

Medicine Details

Category	Details
Generic	Cephradine
Company	Ambee pharmaceuticals ltd
Also available as	Mycef 500 mg capsule Mycef 125 mg pediatric drop Mycef ds 250 mg suspension

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Urinary tract infections
Skin and soft tissue infections

Pharmacology

Semisynthetic broad spectrum bactericidal antibiotic
Active against gram-positive and gram-negative microorganisms
Inhibits cross-linking process in the cell wall of bacteria

Dosage & Administration

For oral administration:
- Adults:
  - Urinary tract infections: 500mg four times daily or 1g twice daily
  - Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily
  - Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily
- Children:
  - Total daily dose of 25 to 50mg/kg given in two or four equally divided doses
  - Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly
  - Maximum daily dosage: 4 gm
- Elderly: The normal adult dose is appropriate. Patients with impaired renal or hepatic function should be monitored during treatment.
For injectable administration:
- Adult: The usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily. For prophylaxis a single preoperative dose of 1-2 gm intramuscularly or intravenously is given.
- Children: The dose is 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection.

Interaction

Concomitant use of nephrotoxic drugs such as aminoglycosides with Cefradine may increase the risk of kidney damage. Diuretics and probenecid enhanced the possibility of renal toxicity.

Contraindications

Cephradine should not be used in patients with known or suspected hypersensitivity to cephalosporins.

Side Effects

Gastro-intestinal disturbances
Hypersensitivity phenomena
Skin reactions
Glossitis
Heartburn
Dizziness
Nausea
Vomiting
Diarrhoea
Abdominal pain
Vaginitis
Candida overgrowth
Urticaria
Skin rashes
Joint pains
Oedema
Fever
Serum sickness like reactions
Anaphylaxis
Confusion
Sleep disturbances
Hyperactivity
Hypertonia
Elevation of blood urea nitrogen

Pregnancy & Lactation

Cephradine is excreted in breast milk and should be used with caution in lactating mothers. Safety in pregnancy has not been established.

Precautions & Warnings

Prolonged use of an anti-infective may result in the development of superinfection due to the emergence of resistant organisms
Administered with care to patients hypersensitive to penicillins
May cause a false positive urine glucose result when Benedict’s or Fehling’s solutions are used in the testing
Dosage adjustment is necessary in renal impairment

Use in Special Populations

Recommended doses for patients with renal impairment and haemodialysis. Regular bacteriological and clinical monitoring is required in chronic urinary tract infections.

Overdose Effects

Symptoms include nausea, vomiting, diarrhoea, and gastric upsets. Treatment is mainly supportive.

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Mycef Suspension should be used within 7-14 days of preparation. Injection solutions should be used within 2 hours at room temperature or within 12 hours when stored at 5°C.