P-Cef 500 mg (Capsule)

Unit Price: ৳ 12.05 (20's pack: ৳ 241.00)

Medicine Details

Category Details
Generic Cephradine
Company Pharmadesh laboratories ltd
Also available as
P cef 125 mg suspension P cef ds 250 mg suspension P cef 125 mg pediatric drop

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections: bronchitis, lobar pneumonia, bronchopneumonia
  • Urinary tract infections: cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in cell wall of bacteria

Dosage & Administration

  • For oral administration in adults, children, and elderly
  • For injectable administration in adults and children
  • Dosage adjustment necessary in renal impairment

Interaction

  • Concomitant use with nephrotoxic drugs may increase risk of kidney damage
  • Diuretics and probenecid enhance possibility of renal toxicity

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Limited to gastro-intestinal disturbances and hypersensitivity phenomena
  • Possible skin reactions, heartburn, dizziness, nausea, vomiting, diarrhoea
  • Rare blood disorders, immune system disorders, psychiatric disorders, nervous system disorders, hepatobiliary disorders, renal and urinary disorders

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk, caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in development of superinfection
  • Administered with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring required

Overdose Effects

  • Non-specific symptoms include nausea, vomiting, diarrhoea, gastric upsets
  • Supportive treatment, gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7-14 days
  • Injection solutions should be used within 2 hours to 12 hours
  • Do not use later than the date of expiry

Related Brands