P-Cef DS 250 mg/5 ml (Powder for Suspension)
100 ml bottle: ৳ 120.45
Medicine Details
| Category | Details |
|---|---|
| Generic | Cephradine |
| Company | Pharmadesh laboratories ltd |
| Also available as |
Title
- P-Cef DS
Categories
- Medicine
- Antibiotic
- First generation Cephalosporin
Description
- P-Cef DS is a semisynthetic broad-spectrum bactericidal antibiotic
- Active against infections caused by both gram-positive and gram-negative microorganisms
- Indicated for upper and lower respiratory tract infections, urinary tract infections, skin and soft tissue infections
- Contains Cephradine as the active ingredient
DosageAndAdministration
- Oral and injectable administration available
- Adult dosage for urinary tract infections, respiratory tract infections, skin and soft tissue infections
- Children dosage for otitis media, maximum daily dosage
- Elderly and patients with impaired renal or hepatic function monitoring required
Indications
- Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
- Specifically for upper respiratory tract infections, lower respiratory tract infections, urinary tract infections, skin and soft tissue infections
- Susceptible microorganisms include Staphylococci, Streptococci, Escherichia coli, Klebsiella spp, Proteus mirabilis, Haemophilus influenza, Shigella spp, Salmonella spp, Neisseria spp
ModeOfAction
- Cephradine inhibits cross-linking process in the cell wall of bacteria leading to lysis
Interaction
- Concomitant use of nephrotoxic drugs may increase the risk of kidney damage
- Diuretics and probenecid enhance the possibility of renal toxicity
Contraindications
- Not to be used in patients with known or suspected hypersensitivity to cephalosporins
SideEffects
- Gastro-intestinal disturbances
- Hypersensitivity phenomena
- Skin reactions
- Blood and lymphatic system disorders
- Immune system disorders
- Psychiatric and nervous system disorders
- Hepatobiliary and renal disorders
- Investigations related reactions
PregnancyAndLactation
- Safety in pregnancy not established
- Excreted in breast milk, caution advised in lactating mothers
PrecautionsAndWarnings
- Prolonged use may result in the development of superinfection
- Administer with care to patients hypersensitive to penicillins
- Cephalosporin antibiotics may cause a positive result in Coombs' testing
- May cause a false positive urine glucose result with certain tests
- Dosage adjustment necessary in renal impairment
- Contains lactose, not suitable for patients with specific hereditary problems
SpecialPopulations
- Recommended doses for patients with renal impairment and on haemodialysis
- Higher doses may be required for chronic or severe infections
- Regular bacteriological and clinical monitoring required for chronic urinary tract infections
- Paediatric dosages should not exceed those specified for adults
OverdoseEffects
- Non-specific symptoms such as nausea, vomiting, diarrhea, and gastric upsets
- Supportive treatment required, gastric lavage in case of large ingestion
TherapeuticClass
- First generation Cephalosporins
StorageConditions
- Suspension should be freshly prepared
- Reconstituted suspension should be used within 7-14 days based on storage temperature
- Injection solutions should be used within 2-12 hours based on storage temperature
- Do not use later than the expiry date, keep out of reach of children
- Dispensed only on the prescription of a registered physician
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