Procef 250 mg (Capsule)

Unit Price: ৳ 6.50 (6 x 4: ৳ 156.00)
Strip Price: ৳ 26.00

Medicine Details

Category Details
Generic Cephradine
Company Incepta pharmaceuticals ltd
Also available as
Procef 500 mg capsule Procef 125 mg suspension Procef fort 250 mg suspension Procef 125 mg pediatric drop Procef 500 mg injection Procef 1 gm injection

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Susceptible microorganisms
  • Sensitivity to Gram-positive bacteria
  • Sensitivity to Gram-negative bacteria

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Activity against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacteria cell wall
  • Formation of cell wall with pores
  • External osmotic pressure leading to bacteria lysis

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Total daily dose for different types of infections
  • Dosage adjustment in renal and hepatic impairment

Interaction

  • Nephrotoxic drugs interaction
  • Diuretics interaction
  • Probenecid interaction

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen
  • Serum creatinine elevation
  • Liver enzyme disturbances
  • Transient hepatitis
  • Cholestatic jaundice

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk
  • Caution in lactating mothers
  • Risk of dizziness

Precautions & Warnings

  • Superinfection risk
  • Cross-sensitivity with penicillins
  • Positive Coombs’ testing
  • False positive urine glucose result
  • Lactose content
  • Renal impairment dosage adjustment

Use in Special Populations

  • Doses for renal impairment patients
  • Doses for patients on haemodialysis
  • Higher doses for chronic or severe infections
  • Duration of treatment for specific infections

Overdose Effects

  • Non-specific symptoms
  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment
  • Gastric lavage if necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension storage period
  • Injection solutions storage period
  • Effect of storage temperature on potency
  • Variation in reconstituted solution color
  • Dispensing requirements

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