Procef 125 mg/1.25 ml (Pediatric Drops)

Indications

• Treatment of Upper respiratory tract infections
• Treatment of Lower respiratory tract infections
• Treatment of Urinary tract infections
• Treatment of Skin and soft tissue infections
• Active against Gram-positive bacteria
• Active against Gram-negative bacteria

Pharmacology

• Broad spectrum bactericidal antibiotic
• Active against both gram-positive and gram-negative microorganisms
• Inhibition of cross-linking process in bacteria's cell wall
• Resultant formation of cell wall with porous structure leading to bacterial lysis

Dosage & Administration

• Adult dosage for Urinary tract infections
• Adult dosage for Respiratory tract infections
• Adult dosage for Skin and soft tissue infections
• Children dosage for various infections
• Elderly dosage considerations
• Injectable dosage for Adults
• Injectable dosage for Children
• Maximum daily dosage
• Dosage adjustment in renal impairment

Interaction

• Concomitant use of nephrotoxic drugs with Cefradine
• Enhanced risk of kidney damage with diuretics and probenecid

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

• Gastro-intestinal disturbances
• Hypersensitivity reactions
• Skin reactions
• Glossitis
• Heartburn
• Dizziness
• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Vaginitis
• Candida overgrowth
• Blood disorders
• Fever
• Serum sickness like reactions
• Anaphylaxis
• Psychiatric disorders
• Nervous system disorders
• Hepatobiliary disorders
• Renal and urinary disorders
• Elevation of blood urea nitrogen
• Elevation of serum creatinine
• Elevation of liver enzymes
• Reversible interstitial nephritis

Pregnancy & Lactation

• No established safety in pregnancy
• Use with caution in lactating mothers
• Potential to cause dizziness

Precautions & Warnings

• Risk of superinfection with prolonged use
• Careful administration in patients hypersensitive to penicillins
• Potential positive result in Coombs’ testing
• Potential false positive urine glucose result
• Dosage adjustment in renal impairment
• Lactose content caution for specific hereditary conditions

Use in Special Populations

• Recommended doses for patients with renal impairment
• Recommendations for patients on chronic, intermittent haemodialysis
• Higher doses may be required for chronic or severe infections
• Continued treatment for persistent infections
• Transfer from intramuscular/intravenous to oral treatment

Overdose Effects

• Non-specific symptoms such as nausea, vomiting, and diarrhoea
• Supportive treatment
• Gastric lavage for large ingestions

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Freshly prepared Suspension
• Reconstituted Suspension shelf life
• Injection solutions shelf life
• Effect of temperature on solution potency
• Usage within expiry date
• Storage away from children

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