Lopin 5 mg (Tablet)
Unit Price: ৳ 3.00 (30's pack: ৳ 90.01)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Edruc limited |
Indications
- Treatment of essential hypertension
- Treatment of angina pectoris
- Treatment of vasospastic angina
- Efficacious as monotherapy in hypertension
- May be used in combination with other antihypertensive agents
- Efficacious as monotherapy in chronic stable angina pectoris
- May be used in combination with other antianginal agents
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Influences myocardial cells and cells of vascular smooth muscle
- Results in vasodilation and reduced peripheral resistance
- Increases coronary blood flow and reflex increase in coronary heart rate
- Increases myocardial oxygen supply and cardiac output
Dosage & Administration
- Usual dose for hypertension: 5 mg once daily
- Maximum dose for hypertension: 10 mg once daily
- Usual dose for angina: 5-10 mg once daily
- Lower dose for elderly and patients with hepatic insufficiency
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers in patients with severely impaired cardiac left ventricular function
- No interaction between Lopin and Digoxin in healthy volunteers
- No interaction between Lopin and Cimetidine in healthy volunteers
- No significant alteration of Warfarin effect on prothrombin time by Lopin
- Food does not alter absorption rate of Lopin
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnancy
Side Effects
- Common adverse effects: dizziness, flushing, headache, hypotension, peripheral edema
- Other effects: gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain, mental depression, paradoxical increase in ischaemic chest pain
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy only if potential benefit justifies potential risk to fetus
- Recommendation to discontinue nursing while Amlodipine is administered due to unknown excretion in human milk
Precautions & Warnings
- Precaution in patients with hepatic impairment
- Precaution during pregnancy and breastfeeding
Use in Special Populations
- Dosing for children with hypertension from 6 to 17 years: 2.5 mg once daily, up-titrated to 5 mg once daily if necessary
- No studied dosages in excess of 5 mg daily in pediatric patients
- Effect on blood pressure in patients under 6 years old not known
- Lopin used at similar doses in elderly or younger patients is equally well tolerated
- Normal dosage recommended in the elderly
- Careful dosage selection in patients with mild to moderate hepatic impairment
- Initiate Lopin at lowest dose in severe hepatic impairment
Overdose Effects
- Symptoms: excessive peripheral vasodilatation, reflex tachycardia, systemic hypotension, shock
- Management: active cardiovascular support, monitoring of cardiac and respiratory function, elevation of extremities, attention to circulating fluid volume and urine output, use of vasoconstrictor, intravenous calcium gluconate, potential gastric lavage
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep out of reach of children
- Store in a cool & dry place, protected from light