Roxicef 500 mg (Capsule)

Unit Price: ৳ 12.55 (5 x 4: ৳ 251.00)
Strip Price: ৳ 50.20

Medicine Details

Category Details
Generic Cephradine
Company Popular pharmaceuticals ltd
Also available as
Roxicef 125 mg suspension

Indications

  • Infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections like sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections like bronchitis, lobar pneumonia, bronchopneumonia
  • Urinary tract infections like cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections like abscess, cellulitis, furunculosis, impetigo

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Cell wall inhibitor
  • Active against penicillinase producing and non-producing staphylococci

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosage adjustment in renal impairment
  • Maximum daily dosage: 4 gm
  • Prophylactic dose for adults and children

Interactions

  • Nephrotoxic drug interactions
  • Diuretics and probenecid interactions

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Rare side effects: glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, vaginitis, candida overgrowth
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen, serum creatinine, alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administer with care to patients hypersensitive to penicillins
  • Coombs’ testing
  • False positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose. Avoid in patients with rare hereditary problems of galactose intolerance

Use in Special Populations

  • Dosage recommendations for patients with renal impairment
  • Higher doses required for chronic or severe infections
  • Treatment duration in persistent infections

Overdose Effects

  • Non-specific symptoms like nausea, vomiting, diarrhoea, gastric upsets
  • Treatment is mainly supportive
  • Gastric lavage may be necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted Suspension usage duration
  • Reconstituted Injection solutions usage duration
  • Variations in solution color
  • Expiry date caution
  • Keep out of the reach of children
  • Dispensed only on prescription

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