M-Card 5 mg (Tablet)
Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Zenith pharmaceuticals ltd |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
- Monotherapy in hypertension treatment
- Monotherapy in chronic stable angina pectoris treatment
- Vasospastic angina treatment
- Combination therapy with other antihypertensive agents
- Combination therapy with other antianginal agents
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Influences myocardial cells
- Influences specialized conducting system of the heart
- Influences vascular smooth muscle
- Results in vasodilation
- Reduces peripheral resistance
- Increases coronary blood flow
- Increases myocardial oxygen supply
- Increases cardiac output
Dosage & Administration
- Usual dose: 5 mg once daily for hypertension
- Usual dose: 5 to 10 mg for angina
- Maximum dose: 10 mg once daily
- Starting dose for elderly with hepatic insufficiency: 2.5 mg once daily
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers in patients with impaired cardiac function
- No interaction with Digoxin
- No interaction with Cimetidine
- No significant alteration of Warfarin effect on prothrombin time
- Food does not alter absorption rate
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnancy
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Excessive fall in blood pressure
- Ischaemic chest pain at start of treatment
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- No adequate and well-controlled studies in pregnant women
- Should be used during pregnancy if benefit justifies risk to fetus
- Not known whether excreted in human milk
- Discontinuation of nursing while administered
Precautions & Warnings
- Should be taken in patients with hepatic impairment
- Precaution during pregnancy and breastfeeding
Use in Special Populations
- Pediatric dosing for hypertension
- Effect on blood pressure in children under 6 years is not known
- Elderly tolerance similar to younger patients
- Normal dosage recommended for renal impairment
- Dosing caution in mild to moderate hepatic impairment
- Initiate at lowest dose for severe hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Management for hypotension due to overdose
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep out of reach of children
- Store in cool & dry place
- Protected from light