Sefin 500 mg (Capsule)

Unit Price: ৳ 12.59 (5 x 4: ৳ 251.80)
Strip Price: ৳ 50.36

Medicine Details

Category Details
Generic Cephradine
Company Orion pharma ltd
Also available as
Sefin 250 mg capsule Sefin 125 mg suspension Sefin ds 250 mg suspension Sefin 125 mg pediatric drop Sefin 250 mg injection Sefin 500 mg injection Sefin 1 gm injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections: bronchitis (acute and chronic), lobar pneumonia, bronchopneumonia
  • Urinary tract infections: cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process of bacterial cell wall

Dosage & Administration

  • Oral and injectable administration
  • Adult dosage for urinary tract infections, respiratory tract infections, and skin and soft tissue infections
  • Children's dosage for otitis media
  • Elderly and impaired renal or hepatic function monitoring

Interaction

  • Nephrotoxic drug interaction
  • Enhanced risk of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions, glossitis, dizziness, nausea, vomiting, diarrhoea, abdominal pain, vaginitis, candida overgrowth
  • Rare blood, immune, psychiatric, nervous system, hepatobiliary, renal, and urinary disorders
  • Elevation of blood urea nitrogen, serum creatinine, liver enzyme disturbances

Pregnancy & Lactation

  • Safety not established in pregnancy
  • Excreted in breast milk, caution in lactating mothers

Precautions & Warnings

  • Risk of superinfection
  • Administration with care to penicillin-hypersensitive patients
  • Positive Coombs’ testing
  • Causes false positive urine glucose result with specific testing
  • Dosage adjustment in renal impairment
  • Contains lactose, caution in patients with rare hereditary problems

Use in Special Populations

  • Recommended doses for patients with renal impairment and haemodialysis
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring for urinary tract infections
  • No exceeding of paediatric dosages

Overdose Effects

  • Non-specific symptoms: nausea, vomiting, diarrhoea, gastric upsets
  • Supportive treatment, gastric lavage if necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension usability timeframe
  • Injection solution usability timeframe
  • Expiry date adherence
  • Keep out of reach of children, dispensed only on prescription

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