Sefin DS 250 mg/5 ml (Powder for Suspension)

50 ml bottle: ৳ 60.42

Medicine Details

Category Details
Generic Cephradine
Company Orion pharma ltd
Also available as
Sefin 250 mg capsule Sefin 500 mg capsule Sefin 125 mg suspension Sefin 125 mg pediatric drop Sefin 250 mg injection Sefin 500 mg injection Sefin 1 gm injection

Product Title

  • Sefin DS

Product Category

  • Medicine
  • Antibiotic

Description

  • Sefin DS is a broad-spectrum bactericidal antibiotic indicated for the treatment of various infections caused by sensitive Gram-positive and Gram-negative bacteria.

Color Options

  • N/A

Dimensions

  • N/A

Materials

  • Cephradine
  • Peptidoglycan

Pharmacological Action

  • Cephradine inhibits cross-linking process in the cell wall of bacteria, causing the formation of cell wall with pores and eventual lysis of bacteria due to external osmotic pressure.

Dosage Form

  • Tablets
  • Suspension
  • Injection

Usability Features

  • Oral Administration
  • Injectable Administration

Recommended Dosage

  • 500mg - 1g for adults with urinary tract infections
  • 250mg - 1g for adults with respiratory tract infections
  • 250mg - 1g for adults with skin and soft tissue infections
  • 25-50mg/kg for children
  • Maximum daily dosage: 4g for adults

Interaction

  • Increased risk of kidney damage when used with nephrotoxic drugs such as aminoglycosides
  • Enhanced possibility of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity reactions
  • Skin reactions
  • Blood disorders
  • Liver and renal disturbances
  • Elevation of blood urea nitrogen
  • Serum creatinine
  • Alanine aminotransferase
  • Aspartate aminotransferase
  • Total bilirubin
  • Alkaline phosphatase

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excretion in breast milk, caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administer with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result with certain tests
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, caution in patients with rare hereditary problems

Use in Special Populations

  • Renal Impairment dosing recommendations
  • Higher doses may be required for severe infections
  • Regular bacteriological and clinical monitoring for chronic urinary tract infections

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, and diarrhoea

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7-14 days
  • Injection solutions should be used within 2 hours at room temperature
  • Potency of solutions retained for 12 hours when stored at 5°C
  • Do not use beyond expiry date
  • Keep out of reach of children
  • To be dispensed only on prescription of a registered physician

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