Sefin 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 50.35

Medicine Details

Category Details
Generic Cephradine
Company Orion pharma ltd
Also available as
Sefin 250 mg capsule Sefin 500 mg capsule Sefin 125 mg suspension Sefin ds 250 mg suspension Sefin 250 mg injection Sefin 500 mg injection Sefin 1 gm injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections (sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media)
  • Lower respiratory tract infections (bronchitis, lobar pneumonia, bronchopneumonia)
  • Urinary tract infections (cystitis, urethritis, pyelonephritis)
  • Skin and soft tissue infections (abscess, cellulitis, furunculosis, impetigo)

Pharmacology

  • Semisynthetic broad-spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in cell walls of bacteria

Dosage & Administration

  • Oral administration for adults
  • Oral administration for children
  • Injectable administration for adults
  • Injectable administration for children
  • Elderly dosage considerations
  • Dosage adjustments in renal impairment

Interaction

  • Concomitant use of nephrotoxic drugs
  • Enhanced risk of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Thrombocytopenia
  • Agranulocytosis
  • Fever
  • Anaphylaxis
  • Confusion
  • Liver enzyme disturbances
  • Transient hepatitis
  • Reversible interstitial nephritis
  • Elevation of blood urea nitrogen

Pregnancy & Lactation

  • Safety not established in pregnancy
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administration with care to patients hypersensitive to penicillins
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose
  • Caution in patients with rare hereditary problems

Use in Special Populations

  • Recommended doses for renal impairment
  • Additional information for all patients
  • Higher doses may be required for chronic or severe infections
  • Monitoring required for urinary tract infections
  • Transfer from intramuscular/intravenous to oral treatment

Overdose Effects

  • Non-specific symptoms (nausea, vomiting, diarrhea, gastric upsets)
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Preparation and usage guidelines for suspension
  • Storage duration for reconstituted solutions
  • Potency retention at different temperatures
  • Dispensing only on prescription

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