Sefin 500 mg/vial (IM/IV Injection)
500 mg vial: ৳ 50.35
Medicine Details
| Category | Details |
|---|---|
| Generic | Cephradine |
| Company | Orion pharma ltd |
| Also available as |
Indications
- Upper respiratory tract infections
- Lower respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
Pharmacology
- Bactericidal antibiotic
- Active against gram-positive and gram-negative microorganisms
- Inhibits cross-linking process in bacteria cell wall
Dosage & Administration
- For oral administration - Adults:
- 500mg four times daily
- 1g twice daily
- For oral administration - Children:
- Total daily dose of 25 to 50mg/kg
- Maximum daily dosage: 4 gm
- For injectable administration - Adult:
- 2-4 gm daily in four equally divided doses up to 8 gm daily
- Prophylaxis dose: 1-2 gm intramuscularly or intravenously
- For injectable administration - Children:
- 50-100 mg/kg daily in four equally divided doses
- Up to 300 mg/kg daily in severe infection
Interaction
- Risk of kidney damage with nephrotoxic drugs
- Enhanced renal toxicity with diuretics and probenecid
Contraindications
- Hypersensitivity to cephalosporins
Side Effects
- Gastro-intestinal disturbances
- Hypersensitivity reactions
- Glossitis
- Dizziness
- Nervousness
- Reversible interstitial nephritis
Pregnancy & Lactation
- Excretion in breast milk
- Caution in lactating mothers
- Caution in pregnancy due to limited safety data
Precautions & Warnings
- Risk of superinfection with prolonged use
- Care with penicillin-sensitive patients
- Coombs’ testing caution
- Possible false positive urine glucose result
- Dosage adjustment for renal impairment
- Contains lactose
Use in Special Populations
- Recommended doses for renal impairment
- Higher doses for chronic or severe infections
- Regular bacteriological and clinical monitoring for urinary tract infections
Overdose Effects
- Non-specific symptoms
- Supportive treatment
- Gastric lavage for large ingestions
Therapeutic Class
First generation Cephalosporins
Storage Conditions
- Freshly prepared suspension
- Reconstituted suspension within 7-14 days
- Injection solutions within 2 hours at room temperature or 12 hours at 5°C
- Retain potency for 12 hours
- Dispensed on prescription