Sefin 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 50.35

Medicine Details

Category Details
Generic Cephradine
Company Orion pharma ltd
Also available as
Sefin 250 mg capsule Sefin 500 mg capsule Sefin 125 mg suspension Sefin ds 250 mg suspension Sefin 125 mg pediatric drop Sefin 250 mg injection Sefin 1 gm injection

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacteria cell wall

Dosage & Administration

  • For oral administration - Adults:
    • 500mg four times daily
    • 1g twice daily
  • For oral administration - Children:
    • Total daily dose of 25 to 50mg/kg
    • Maximum daily dosage: 4 gm
  • For injectable administration - Adult:
    • 2-4 gm daily in four equally divided doses up to 8 gm daily
    • Prophylaxis dose: 1-2 gm intramuscularly or intravenously
  • For injectable administration - Children:
    • 50-100 mg/kg daily in four equally divided doses
    • Up to 300 mg/kg daily in severe infection

Interaction

  • Risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity reactions
  • Glossitis
  • Dizziness
  • Nervousness
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Excretion in breast milk
  • Caution in lactating mothers
  • Caution in pregnancy due to limited safety data

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Care with penicillin-sensitive patients
  • Coombs’ testing caution
  • Possible false positive urine glucose result
  • Dosage adjustment for renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for renal impairment
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring for urinary tract infections

Overdose Effects

  • Non-specific symptoms
  • Supportive treatment
  • Gastric lavage for large ingestions

Therapeutic Class

First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension within 7-14 days
  • Injection solutions within 2 hours at room temperature or 12 hours at 5°C
  • Retain potency for 12 hours
  • Dispensed on prescription

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