Sefrad 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 95.29

Medicine Details

Category Details
Generic Cephradine
Company Synovia pharma plc
Also available as
Sefrad 250 mg capsule Sefrad 500 mg capsule Sefrad ds 250 mg suspension Sefrad 125 mg pediatric drop Sefrad 500 mg injection

Indications

  • Treatment of infections caused by sensitive Gram-positive bacteria
  • Treatment of infections caused by sensitive Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacteria cell wall
  • Main site of action is bacteria cell wall
  • Active against penicillinase producing and nonproducing staphylococci

Dosage & Administration

  • For oral administration in adults and children
  • For urinary tract infections, respiratory tract infections, and skin and soft tissue infections
  • Dosage adjustment for elderly, renal impairment, and hepatic function
  • For injectable administration in adults and children
  • Maximum daily dosage

Interaction

  • Concomitant use of nephrotoxic drugs
  • Enhanced risk of renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Blood disorders
  • Fever
  • Serum sickness like reactions
  • Anaphylaxis
  • Psychiatric disorders
  • Nervous system disorders
  • Liver enzyme disturbances
  • Transient hepatitis
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • No established safety in pregnancy
  • Excreted in breast milk
  • Caution in lactating mothers
  • Potential to cause dizziness

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administration with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose
  • Not to be taken by patients with rare hereditary problems

Use in Special Populations

  • Recommended doses for renal impairment
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring for urinary tract infections
  • Restrictions on paediatric dosages
  • Continuing therapy for persistent infections

Overdose Effects

  • Non-specific symptoms
  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment
  • Gastric lavage for large ingestions

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension shelf life
  • Injection solutions shelf life
  • Retention of potency in refrigerated solutions
  • Dispensing only on prescription of registered physician

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