Sefrad DS 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 130.39

Medicine Details

Category Details
Generic Cephradine
Company Synovia pharma plc
Also available as
Sefrad 250 mg capsule Sefrad 500 mg capsule Sefrad 125 mg suspension Sefrad 125 mg pediatric drop Sefrad 500 mg injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Susceptible microorganisms (Staphylococci, Streptococci, Escherichia coli, Klebsiella spp, etc.)

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in cell wall of bacteria
  • Bacteria lysis due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Recommended doses for urinary tract, respiratory tract, and skin/soft tissue infections
  • Dosage adjustment for renal impairment
  • Maximum daily dosage for children

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Rare side effects like glossitis, heartburn, dizziness, nausea, vomiting, etc.
  • Rare blood and lymphatic system disorders, immune system disorders, psychiatric disorders

Pregnancy & Lactation

  • No demonstrated teratogenicity in animal studies
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Care for patients hypersensitive to penicillins
  • Potential positive Coombs’ testing result
  • Possible false positive urine glucose result
  • Dosage adjustment for renal impairment
  • Lactose content caution for specific patient groups

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Additional information for all patients regarding dosage and treatment duration

Overdose Effects

  • Non-specific symptoms like nausea, vomiting, and gastric upsets
  • Supportive treatment
  • Gastric lavage in case of large ingestion

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Expiry for reconstituted suspension
  • Potency retention for injection solutions
  • Dispensing under prescription

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