Sefrad 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 65.20

Medicine Details

Category Details
Generic Cephradine
Company Synovia pharma plc
Also available as
Sefrad 250 mg capsule Sefrad 500 mg capsule Sefrad 125 mg suspension Sefrad ds 250 mg suspension Sefrad 500 mg injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in cell walls of bacteria
  • Causes lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • For oral administration - Adults:
    • Urinary tract infections
    • Respiratory tract infections
    • Skin and soft tissue infections
  • For oral administration - Children:
    • Total daily dose based on weight
    • Otitis media
    • Maximum daily dosage
  • For injectable administration - Adult:
    • Usual dose
    • Prophylaxis dose
  • For injectable administration - Children:
    • Dose based on weight

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Possibility of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Psychiatric disorders
  • Nervous system disorders
  • Hepatobiliary disorders
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen, serum creatinine, alanine aminotransferase, aspartate aminotransferase, total bilirubin, alkaline phosphatase

Pregnancy & Lactation

  • Excretion in breast milk
  • Caution in lactating mothers
  • Possible dizziness

Precautions & Warnings

  • Risk of superinfection with prolonged use
  • Cross-sensitivity with penicillins
  • Potential positive result in Coombs’ testing
  • Potential false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Dosing recommendations for haemodialysis patients
  • Higher doses may be required for chronic or severe infections
  • Continued treatment for persistent infections

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, and gastric upsets
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted Suspension shelf life
  • Injection solutions shelf life
  • Variation in color does not affect potency
  • Dispensing only on physician's prescription

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