Sefril 250 mg (Capsule)

Unit Price: ৳ 8.03 (5 x 4: ৳ 160.60)
Strip Price: ৳ 32.12

Medicine Details

Category Details
Generic Cephradine
Company Acme laboratories ltd
Also available as
Sefril 500 mg capsule Sefril 125 mg suspension Sefril ds 250 mg suspension Sefril 125 mg pediatric drop

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Susceptible microorganisms
  • Staphylococci
  • Streptococci
  • E. coli
  • Klebsiella spp
  • Proteus mirabilis
  • Haemophilus influenza
  • Shigella spp
  • Salmonella spp
  • Neisseria spp

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacterial cell walls
  • Cell wall contains peptidoglycan
  • Lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Different dosage for urinary tract infections, respiratory tract infections, skin and soft tissue infections
  • Dosage adjustment for elderly, renal or hepatic impairment
  • Maximum daily dosage

Interaction

  • Nephrotoxic drugs
  • Diuretics enhance renal toxicity

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth
  • Blood disorders
  • Fever
  • Anaphylaxis
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Care with patients hypersensitive to penicillins
  • Positive result in Coombs’ testing
  • False positive urine glucose result with certain tests
  • Dosage adjustment in renal impairment
  • Contains lactose

Use in Special Populations

  • Renal impairment
  • Haemodialysis
  • Recommended doses

Overdose Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Gastric upsets
  • Symptomatic treatment

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted suspension expiry
  • Injection solution expiry
  • Retention of potency
  • Storage period

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