Sefril DS 250 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 120.82

Medicine Details

Category Details
Generic Cephradine
Company Acme laboratories ltd
Also available as
Sefril 250 mg capsule Sefril 500 mg capsule Sefril 125 mg suspension Sefril 125 mg pediatric drop

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in the cell wall of bacteria

Dosage & Administration

  • Adult dosage for urinary tract infections
  • Adult dosage for respiratory tract infections
  • Adult dosage for skin and soft tissue infections
  • Children dosage for otitis media
  • Maximum daily dosage for children
  • Dosage for elderly and patients with impaired renal or hepatic function
  • Usual injectable dose for adults and prophylaxis
  • Injectable dose for children
  • Dosage for patients with renal impairment
  • Additional information for all patients
  • Transfer from intramuscular/intravenous to oral treatment

Interaction

  • Concomitant use of nephrotoxic drugs
  • Enhanced risk of kidney damage with diuretics
  • Enhanced risk of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Joint pains
  • Oedema
  • Blood disorders
  • Fever
  • Confusion
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Animal studies demonstrate no teratogenicity
  • Excretion in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administer with care to patients hypersensitive to penicillins
  • Cephalosporin antibiotics may cause a positive result in Coombs’ testing
  • May cause a false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose, not for patients with rare hereditary problems

Use in Special Populations

  • Recommended doses for patients with renal impairment
  • Higher doses may be required for chronic or severe infections
  • Recommendations for chronic urinary tract infections
  • Paediatric dosages not to exceed those specified for adults
  • Transfer from intramuscular/intravenous therapy to oral treatment

Overdose Effects

  • Non-specific symptoms
  • Treatment is mainly supportive
  • Necessity of gastric lavage if a large amount has been ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Reconstituted Suspension usage timeline
  • Injection solutions usage timeline
  • Potency retention at 5°C
  • Do not use beyond expiry date
  • Dispense only on prescription of a registered physician

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