Sefro 500 mg (Capsule)

Unit Price: ৳ 15.00 (4 x 6: ৳ 360.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Cephradine
Company Navana pharmaceuticals ltd
Also available as
Sefro 250 mg capsule Sefro 125 mg suspension Sefro ds 250 mg suspension Sefro 125 mg pediatric drop

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacteria

Dosage & Administration

  • Oral administration - Adults:
    • Urinary tract infections
    • Respiratory tract infections
    • Skin and soft tissue infections
  • Oral administration - Children:
    • Total daily dose of 25 to 50mg/kg
    • Otitis media
    • Maximum daily dosage: 4 gm
  • Injectable administration - Adult:
    • Usual dose is 2-4 gm daily in four equally divided doses
    • Prophylaxis dose of 1-2 gm intramuscularly or intravenously
  • Injectable administration - Children:
    • Dose is 50-100 mg/kg daily in four equally divided doses
    • Up to 300 mg/kg daily in severe infection

Interaction

  • Concomitant use of nephrotoxic drugs may increase the risk of kidney damage
  • Diuretics and probenecid enhance possibility of renal toxicity

Contraindications

  • Known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Nausea
  • Vomiting
  • Diarrhoea
  • Renal and urinary disorders
  • Elevation of blood urea nitrogen

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in the development of superinfection
  • Administered with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result
  • Dosage adjustment is necessary in renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for patients not on haemodialysis
  • Doses for patients on chronic, intermittent haemodialysis
  • Higher doses may be required for chronic or severe infections

Overdose Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment recommended
  • Gastric lavage may be necessary

Therapeutic Class

First generation Cephalosporins

Storage Conditions

  • Prepared Suspension should be used within 7-14 days
  • Injection solutions should be used within 2 hours if kept at room temperature
  • Retains potency for 12 hours when stored at 5°C
  • Variation in color does not affect potency

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