Sefro 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 85.00

Medicine Details

Category Details
Generic Cephradine
Company Navana pharmaceuticals ltd
Also available as
Sefro 250 mg capsule Sefro 500 mg capsule Sefro ds 250 mg suspension Sefro 125 mg pediatric drop

Title

  • Sefro Antibiotic Medicine

Categories

  • Pharmaceuticals
  • Antibiotics
  • Medicine

Description

  • Cephradine is a semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Indicated for the treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Contraindicated in patients with known or suspected hypersensitivity to cephalosporins
  • Can be administered orally and via injection

Color Options

  • N/A

Dosage Form

  • Tablet
  • Injection
  • Suspension

Recommended Dosage

  • Adults: 500mg-1g four times daily or as directed by a healthcare professional
  • Children: 25-50mg/kg given in two or four equally divided doses or as directed by a healthcare professional

Pharmacological Action

  • Inhibits cross-linking process in the cell wall of bacteria
  • Causes lysis of bacteria due to external osmotic pressure

Administration Method

  • Oral
  • Injectable

Interaction

  • Concomitant use of nephrotoxic drugs with Cefradine may increase the risk of kidney damage
  • Diuretics and probenecid enhanced the possibility of renal toxicity

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Vaginitis
  • Candida overgrowth

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk, caution advised for lactating mothers

Precautions & Warnings

  • Prolonged use may result in the development of superinfection due to the emergence of resistant organisms
  • Administered with care to patients hypersensitive to penicillins
  • May cause a false positive urine glucose result with certain testing methods
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, caution for patients with rare hereditary problems

Use in Special Populations

  • Dosage adjustments for patients with renal impairment
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring required for chronic urinary tract infections
  • Paediatric dosages should not exceed those specified for adults

Overdose Effects

  • Non-specific symptoms including nausea, vomiting, diarrhoea, and gastric upsets
  • Treatment is mainly supportive, gastric lavage may be necessary if a large amount has been ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Suspension should be freshly prepared and used within specified timeframes
  • Injection solutions should be used within 2 hours when kept at room temperature
  • Retains potency for 12 hours when stored at 5°C
  • Do not use later than the date of expiry

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