Pristin 5 mg (Tablet)
Unit Price: ৳ 5.00 (30's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Novo healthcare and pharma ltd |
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Dihydropyridine calcium-channel blocker
- Long duration of action
- Vasodilation
- Reduced peripheral resistance
- Increased coronary blood flow
- Reflex increase in coronary heart rate
Dosage & Administration
- Usual dose of 5 mg once daily
- Maximum dose of 10 mg once daily
- Lower dose for elderly and patients with hepatic insufficiency
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers in patients with markedly impaired cardiac left ventricular function
- Absence of interaction between Pristin and Digoxin
- No interaction between Pristin and Cimetidine
- Pristin did not alter the effect of Warfarin on prothrombin time
- Food does not alter the rate or extent of absorption of Pristin
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnant woman
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Ischaemic chest pain
- Excessive fall in blood pressure
- Rashes
- Fever
- Abnormalities in liver function
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy if potential benefit justifies potential risk to the fetus
- Discontinue nursing while Amlodipine is administered
Precautions & Warnings
- Precaution in patients with hepatic impairment
- Precaution during pregnancy and breastfeeding
Use in Special Populations
- Dosage for children with hypertension from 6 to 17 years of age
- Effect of amlodipine on blood pressure in patients under 6 years of age is not known
- Elderly patients can use similar doses
- Normal dosage recommended in renal impairment
- Caution in dose selection for hepatic impairment
- Initiate at lowest dose in severe hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Clinically significant hypotension calls for active cardiovascular support
- Intravenous calcium gluconate may be beneficial
- Gastric lavage may be worthwhile
- Charcoal may reduce absorption rate
- Dialysis is not likely to be of benefit
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep out of reach of children
- Store in cool & dry place
- Protected from light