Sephar 500 mg (Capsule)
Unit Price: ৳ 12.50 (5 x 6: ৳ 375.00)
Strip Price: ৳ 75.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cephradine |
| Company | Jenphar bangladesh ltd |
| Also available as |
Indications
- Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
- Upper respiratory tract infections
- Lower respiratory tract infections
- Urinary tract infections
- Skin and soft tissue infections
Pharmacology
- Bactericidal antibiotic
- Active against gram-positive and gram-negative microorganisms
- Inhibition of cross-linking process in the cell wall of bacteria
- Cell wall lysis due to external osmotic pressure
Dosage & Administration
- For oral administration - Adults:
- Urinary tract infections: 500mg four times daily or 1g twice daily
- Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily
- Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily
- For oral administration - Children:
- Total daily dose of 25 to 50mg/kg given in two or four equally divided doses
- Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly
- For injectable administration - Adult: 2-4 gm daily in four equally divided doses up to 8 gm daily
- For injectable administration - Children: 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection
Interaction
- Potential risk of kidney damage when used concomitantly with nephrotoxic drugs
- Enhanced possibility of renal toxicity with diuretics and probenecid
Contraindications
Not to be used in patients with known or suspected hypersensitivity to cephalosporins
Side Effects
- Gastro-intestinal disturbances
- Hypersensitivity phenomena
- Skin reactions
- Glossitis
- Heartburn
- Dizziness
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Vaginitis
- Candida overgrowth
- Urticaria
- Skin rashes
- Joint pains
- Oedema
- Blood disorders
- Fever
- Confusion
- Liver enzyme disturbances
- Reversible interstitial nephritis
Pregnancy & Lactation
- No demonstrated teratogenicity in animal studies
- Safety in pregnancy not established
- Excreted in breast milk
- Caution in lactating mothers
- May cause dizziness
Precautions & Warnings
- Prolonged use may result in superinfection
- Administer with care to patients hypersensitive to penicillins
- May cause a false positive urine glucose result
- Dosage adjustment necessary in renal impairment
- Contains lactose - caution in patients with rare hereditary problems
- Renal Impairment: Recommended doses based on creatinine clearance levels
- Paediatric dosages should not exceed those specified for adults
Use in Special Populations
Recommended doses for patients with renal impairment and on chronic, intermittent haemodialysis
Overdose Effects
Non-specific symptoms such as nausea, vomiting, and diarrhoea
Therapeutic Class
First generation Cephalosporins
Storage Conditions
Suspension and injection solutions shelf life, storage, and usage instructions
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