Sicef DS 250 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 70.26

Medicine Details

Category Details
Generic Cephradine
Company Silva pharmaceuticals ltd
Also available as
Sicef 500 mg capsule Sicef 125 mg suspension Sicef 125 mg pediatric drop

Title

  • Sicef DS

Categories

  • Medicine
  • Antibiotics
  • Cephalosporins
  • Pharmacology

Description

  • Sicef DS is indicated for the treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria.
  • Cephradine is a semisynthetic broad spectrum bactericidal antibiotic.

Color options

  • White

Functions

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Bactericidal antibiotic action
  • Inhibition of cross-linking process in bacteria cell walls

Dosage administration

  • For oral and injectable administration
  • Different doses for adults, children, and elderly
  • Dosage adjustment in renal impairment
  • Maximum daily dosage of 4 gm
  • Caution in lactating mothers

Interaction

  • Nephrotoxic drugs such as aminoglycosides may increase the risk of kidney damage when used concomitantly with Cefradine
  • Enhanced possibility of renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Potential blood disorders, immune system disorders, psychiatric disorders, nervous system disorders, hepatobiliary disorders, renal and urinary disorders

Pregnancy lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions warnings

  • Prolonged use may result in the development of superinfection
  • Caution in patients hypersensitive to penicillins
  • Potential positive Coombs’ testing result
  • Potential false positive urine glucose result
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, caution in patients with galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption

Special populations

  • Recommended doses for patients not on haemodialysis
  • Recommendations for patients on chronic, intermittent haemodialysis
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring for chronic urinary tract infections
  • Paediatric dosages should not exceed those specified for adults
  • Transfer from intramuscular/intravenous Sicef DS therapy to oral treatment at the same dosage level

Overdose effects

  • Non-specific symptoms such as nausea, vomiting, and diarrhoea

Therapeutic class

  • First generation Cephalosporins

Storage conditions

  • Freshly prepared suspension
  • Usage within 7-14 days based on storage temperature
  • Injection solutions usage within 2 hours at room temperature
  • Retention of potency for 12 hours when stored at 5°C
  • Variation in color from light to straw yellow does not affect potency
  • Dispensed only on the prescription of a registered physician

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