Sicef 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 45.14

Medicine Details

Category Details
Generic Cephradine
Company Silva pharmaceuticals ltd
Also available as
Sicef 500 mg capsule Sicef 125 mg suspension Sicef ds 250 mg suspension

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacteria cell wall

Dosage & Administration

  • Oral administration - Adults:
    • Urinary tract infections: 500mg-1g four times daily
    • Respiratory tract infections: 250-500mg four times daily
    • Skin and soft tissue infections: 250-500mg four times daily
  • Oral administration - Children:
    • Total daily dose of 25 to 50mg/kg
    • Maximum daily dosage: 4 gm
  • Injectable administration - Adults:
    • Usual dose: 2-4 gm daily in four equally divided doses
  • Injectable administration - Children:
    • Dose: 50-100 mg/kg daily in four equally divided doses

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Common:
    • Gastro-intestinal disturbances
    • Hypersensitivity phenomena
    • Skin reactions
  • Rare:
    • Glossitis
    • Dizziness
    • Nausea
    • Vomiting
    • Diarrhoea
    • Abdominal pain
    • Vaginitis
    • Candida overgrowth
    • Fever
    • Serum sickness like reactions
    • Anaphylaxis
    • Confusion
    • Liver enzyme disturbances
    • Reversible interstitial nephritis

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administration with care to patients hypersensitive to penicillins
  • May cause a false positive urine glucose result
  • Dosage adjustment necessary in renal impairment
  • Contains lactose

Use in Special Populations

  • Recommended doses for patients with renal impairment and on haemodialysis
  • Higher doses may be required for chronic or severe infections

Overdose Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Sicef Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7-14 days
  • Injection solutions should be used within 2 hours (room temperature) or 12 hours (5°C)
  • Do not use later than the date of expiry

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