Sinaceph 250 mg (Capsule)

Unit Price: ৳ 6.80 (4 x 5: ৳ 136.00)
Strip Price: ৳ 34.00

Medicine Details

Category Details
Generic Cephradine
Company Ibn sina pharmaceuticals ltd
Also available as
Sinaceph 500 mg capsule Sinaceph 125 mg suspension Sinaceph ds 250 mg suspension Sinaceph 125 mg pediatric drop Sinaceph 500 mg injection Sinaceph 1 gm injection

Indications

  • Treatment of upper respiratory tract infections
  • Treatment of lower respiratory tract infections
  • Treatment of urinary tract infections
  • Treatment of skin and soft tissue infections
  • Effective against Gram-positive bacteria
  • Effective against Gram-negative bacteria

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in bacterial cell wall
  • Main site of action: cell wall of bacteria

Dosage & Administration

  • Oral administration for adults and children
  • Injectable administration for adults and children
  • Dosage adjustment for renal impairment
  • Maximum daily dosage: 4 gm

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Hypersensitivity to cephalosporins

Side Effects

  • Gastrointestinal disturbances
  • Hypersensitivity phenomena
  • Skin reactions
  • Glossitis
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Liver enzyme disturbances
  • Reversible interstitial nephritis

Pregnancy & Lactation

  • Caution in use during pregnancy
  • Excreted in breast milk
  • Caution in lactating mothers
  • Potential to cause dizziness

Precautions & Warnings

  • Potential for superinfection with prolonged use
  • Risk of cross-sensitivity between beta-lactam antibiotics
  • Positive result in Coombs’ testing
  • False positive urine glucose result
  • Dosage adjustment necessary in renal impairment

Use in Special Populations

  • Recommended doses for renal impairment
  • Higher doses for chronic or severe infections
  • Regular bacteriological and clinical monitoring required

Overdose Effects

  • Non-specific symptoms
  • Nausea
  • Vomiting
  • Diarrhoea
  • Gastric upsets

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepare suspension
  • Reconstituted suspension to be used within 7-14 days
  • Solution potency retention for 2-12 hours
  • Variation in color of reconstituted solutions

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