Sinaceph 500 mg (Capsule)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Cephradine
Company Ibn sina pharmaceuticals ltd
Also available as
Sinaceph 250 mg capsule Sinaceph 125 mg suspension Sinaceph ds 250 mg suspension Sinaceph 125 mg pediatric drop Sinaceph 500 mg injection Sinaceph 1 gm injection

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections

Pharmacology

  • Broad spectrum bactericidal antibiotic
  • Active against gram-positive and gram-negative microorganisms
  • Inhibition of cross-linking process in cell wall
  • Resulting in lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • For oral administration - Adults:
    • 500mg four times daily or 1g twice daily for urinary tract infections
    • 250 to 500mg four times daily or 500mg to 1g twice daily for respiratory tract infections
    • 250 to 500mg four times daily or 500mg to 1g twice daily for skin and soft tissue infections
    • Maximum daily dosage: 4 gm
  • For oral administration - Children:
    • Total daily dose of 25 to 50mg/kg
    • Maximum daily dosage: 4 gm
  • For injectable administration - Adult:
    • 2-4 gm daily in four equally divided doses up to 8 gm daily
    • 1-2 gm prophylactic dose
  • For injectable administration - Children:
    • 50-100 mg/kg daily in four equally divided doses up to 300 mg/kg daily

Interaction

  • Increased risk of kidney damage with nephrotoxic drugs
  • Enhanced renal toxicity with diuretics and probenecid

Contraindications

  • Known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances: Limited essentially to gastrointestinal disturbances
  • Hypersensitivity phenomena: More likely in individuals with previous hypersensitivity
  • Rare side effects:
    • Glossitis
    • Heartburn
    • Dizziness
    • Nausea
    • Vomiting
    • Diarrhoea
    • Abdominal pain
    • Vaginitis
    • Candida overgrowth
    • Skin reactions
    • Joint pains
    • Oedema
  • Other disorders:
    • Blood disorders
    • Fever
    • Psychiatric disorders
    • Liver related disorders
    • Reversible interstitial nephritis
    • Elevation of certain blood parameters

Pregnancy & Lactation

  • Not established safety in pregnancy
  • Excreted in breast milk, caution in lactating mothers

Precautions & Warnings

  • Prolonged use: May result in development of superinfection
  • Cross-sensitivity: Care in patients hypersensitive to penicillins
  • False positive urine glucose result: May occur in testing
  • Dosage adjustment: Necessary in renal impairment
  • Lactose intolerance: Should not be taken by patients with rare hereditary problems

Use in Special Populations

  • Recommended doses for renal impairment
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring for chronic urinary tract infections
  • Dosages should not exceed those specified for adults in pediatric use

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, and diarrhea
  • Supportive treatment
  • Gastric lavage if large amount ingested

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Reconstituted Suspension should be used within 7-14 days
  • Solutions retain potency for 12 hours when stored at 5°C
  • Do not use later than the date of expiry
  • To be dispensed only on the prescription of a registered physician

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