Sinaceph 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 55.00

Medicine Details

Category	Details
Generic	Cephradine
Company	Ibn sina pharmaceuticals ltd
Also available as	Sinaceph 250 mg capsule Sinaceph 500 mg capsule Sinaceph 125 mg suspension Sinaceph ds 250 mg suspension Sinaceph 125 mg pediatric drop Sinaceph 1 gm injection

Indications

Treatment of infections caused by sensitive Gram-positive bacteria
Treatment of infections caused by sensitive Gram-negative bacteria
Treats upper respiratory tract infections like sinusitis, pharyngitis, tonsillitis, bronchitis
Treats lower respiratory tract infections like pneumonia
Treats urinary tract infections like cystitis, pyelonephritis
Treats skin and soft tissue infections like cellulitis, impetigo

Pharmacology

Broad-spectrum bactericidal antibiotic
Active against both gram-positive and gram-negative microorganisms
Inhibits cross-linking in bacterial cell walls
Cell wall lysis due to external osmotic pressure

Dosage & Administration

Oral administration for adults and children
Dosage varies based on infection severity
Dosage adjustment for elderly and patients with impaired renal or hepatic function
Injectable administration for adults and children
Prophylactic doses for preoperative use

Interaction

Risk of kidney damage with concomitant use of nephrotoxic drugs
Enhanced renal toxicity with diuretics and probenecid

Contraindications

Not to be used in patients with known hypersensitivity to cephalosporins

Side Effects

Gastrointestinal disturbances
Hypersensitivity reactions
Skin reactions like rashes
Rare side effects like glossitis, dizziness, nausea
Potential blood disorders, immune system disorders
Psychiatric and nervous system disorders

Pregnancy & Lactation

Safety in pregnancy not established
Excreted in breast milk, caution in lactating mothers

Precautions & Warnings

Risk of superinfection with prolonged use
Caution in patients hypersensitive to penicillins
May cause false positive urine glucose results

Use in Special Populations

Recommended doses for patients with renal impairment
Higher doses may be needed for severe infections
Regular monitoring required for chronic urinary tract infections

Overdose Effects

Non-specific symptoms like nausea, vomiting
Supportive treatment, gastric lavage if necessary

Therapeutic Class

First generation Cephalosporins

Storage Conditions

Sinaceph Suspension should be freshly prepared
Reconstituted Suspension to be used within 7-14 days
Injection solutions should be used within 2 hours

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