SK-cef 250 mg (Capsule)

Unit Price: ৳ 8.00 (8 x 6: ৳ 384.00)

Strip Price: ৳ 48.00

Medicine Details

Category	Details
Generic	Cephradine
Company	Eskayef pharmaceuticals ltd
Also available as	Sk cef 500 mg capsule Sk cef 125 mg suspension Sk cef ds 250 mg suspension Sk cef 125 mg pediatric drop Sk cef 500 mg injection Sk cef 1 gm injection

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Urinary tract infections
Skin and soft tissue infections

Pharmacology

Semisynthetic broad spectrum bactericidal antibiotic
Active against both gram-positive and gram-negative microorganisms
Inhibits cross-linking process of peptidoglycan in cell wall
Causes lysis of bacteria due to external osmotic pressure

Dosage & Administration

For oral administration:
- Adults:
  - Urinary tract infections: 500mg four times daily or 1g twice daily
  - Respiratory tract infections: 250 to 500mg four times daily or 500mg to 1g twice daily
  - Skin and soft tissue infections: 250 to 500mg four times daily or 500mg to 1g twice daily
- Children:
  - Total daily dose of 25 to 50mg/kg given in two or four equally divided doses
  - Otitis media: Total daily dose of 75 to 100mg/kg given in divided doses 6 to 12 hourly
  - Maximum daily dosage: 4 gm
- Elderly: The normal adult dose is appropriate. Patients with impaired renal or hepatic function should be monitored during treatment.
For injectable administration:
- Adult: The usual dose is 2-4 gm daily in four equally divided doses up to 8 gm daily. For prophylaxis a single preoperative dose of 1-2 gm intramuscularly or intravenously is given.
- Children: The dose is 50-100 mg/kg daily in four equally divided doses, up to 300 mg/kg daily in severe infection.

Interaction

Concomitant use of nephrotoxic drugs such as aminoglycosides with Cefradine may increase the risk of kidney damage. Diuretics and probenecid enhance the possibility of renal toxicity.

Contraindications

Cephradine should not be used in patients with known or suspected hypersensitivity to cephalosporins.

Side Effects

Gastro-intestinal disturbances
Hypersensitivity phenomena
Skin reactions
Glossitis
Heartburn
Dizziness
Nausea
Vomiting
Diarrhoea
Abdominal pain
Vaginitis
Candida overgrowth
Fever
Serum sickness like reactions
Anaphylaxis
Confusion
Sleep disturbances
Reversible interstitial nephritis
Elevation of blood urea nitrogen
Liver enzyme disturbances

Pregnancy & Lactation

Animal studies have not demonstrated teratogenicity, safety in pregnancy not established. Cephradine is excreted in breast milk and should be used with caution in lactating mothers. Patients cautioned about operating hazardous machinery.

Precautions & Warnings

Prolonged use may result in superinfection
Care with patients hypersensitive to penicillins
Caution with Coombs’ testing in neonates
May cause false positive urine glucose result with certain tests
Dosage adjustment necessary in renal impairment
Contains lactose
Should not be taken by patients with certain hereditary conditions

Use in Special Populations

Recommended doses for renal impairment
Higher doses may be required for chronic or severe infections
Treatment should continue for at least 2 to 3 days after symptoms have resolved or bacteria have been eradicated
Regular bacteriological and clinical monitoring required for chronic urinary tract infections

Overdose Effects

Non-specific symptoms such as nausea, vomiting, diarrhoea and gastric upsets. Supportive treatment, gastric lavage if large amount ingested.

Therapeutic Class

First generation Cephalosporins

Storage Conditions

SK-cef Suspension should be freshly prepared. Reconstituted Suspension should be used within 7 days if kept at room temperature or within 14 days if kept in a refrigerator. SK-cef Injection solutions should be used within 2 hours when kept at room temperature. When stored at 5°C, solutions retain potency for 12 hours.