Ultrasef 500 mg (Capsule)

Indications

• Treatment of upper respiratory tract infections
• Treatment of lower respiratory tract infections
• Treatment of urinary tract infections
• Treatment of skin and soft tissue infections
• Susceptible microorganisms - Staphylococci, Streptococci, E. coli, Klebsiella spp, etc.

Pharmacology

• Semisynthetic broad spectrum bactericidal antibiotic
• Active against gram-positive and gram-negative microorganisms
• Inhibits cross-linking process in bacteria cell walls
• Causes lysis of bacteria due to external osmotic pressure

Dosage & Administration

• Recommended oral dosage for adults and children
• Maximum daily dosage
• Dosage for injectable administration in adults and children
• Monitoring for patients with impaired renal or hepatic function

Interaction

• Increased risk of kidney damage with concomitant use of nephrotoxic drugs
• Enhanced possibility of renal toxicity with diuretics and probenecid

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

• Gastro-intestinal disturbances
• Hypersensitivity phenomena
• Skin reactions
• Rare effects - Glossitis, heartburn, dizziness, etc.
• Rare blood and lymphatic system disorders
• Rare immune system disorders
• Rare psychiatric and nervous system disorders
• Rare hepatobiliary disorders
• Rare renal and urinary disorders
• Rare elevations in blood and urine parameters

Pregnancy & Lactation

• No established safety in pregnancy
• Excreted in breast milk
• Caution in lactating mothers
• Potential to cause dizziness

Precautions & Warnings

• Development of superinfection with prolonged use
• Care in patients hypersensitive to penicillins
• Potential positive result in Coombs’ testing
• Potential false positive urine glucose result
• Dosage adjustment in renal impairment
• Contains lactose - caution in patients with specific intolerances

Use in Special Populations

• Recommended doses for patients with renal impairment
• Higher doses for chronic or severe infections
• Monitoring required for chronic urinary tract infections
• Transfer from intramuscular/intravenous to oral treatment
• Paediatric dosages should not exceed adult dosages

Overdose Effects

• Non-specific symptoms - nausea, vomiting, diarrhea, gastric upsets
• Supportive treatment
• Gastric lavage for large ingestions

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Freshly prepared suspension
• Usage duration for reconstituted suspension and injection solutions
• Retention of potency based on storage temperature
• Safe storage away from children
• Dispensing only on prescription

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