Velogen 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 82.56

Medicine Details

Category Details
Generic Cephradine
Company General pharmaceuticals ltd
Also available as
Velogen 250 mg capsule Velogen 500 mg capsule

Therapeutic Class

  • First generation Cephalosporins

Indications

  • Treatment of infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis, otitis media
  • Lower respiratory tract infections: bronchitis (acute and chronic), lobar pneumonia, bronchopneumonia
  • Urinary tract infections: cystitis, urethritis, pyelonephritis
  • Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo
  • Susceptible microorganisms: Staphylococci, Streptococci, Streptococcus pyogenes, Streptococcus pneumonia, Escherichia coli, Klebsiella spp, Proteus mirabilis, Haemophilus influenza, Shigella spp, Salmonella spp (including Salmonella typhi), Neisseria spp

Pharmacology

  • Semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in the cell wall of bacteria
  • Main site of action is the cell wall of bacteria
  • Lysis of bacteria occurs due to external osmotic pressure

Dosage & Administration

  • Variable dosage for adults based on infection type and severity
  • Dosage for children based on total daily dose and specific infections
  • Maximum daily dosage: 4 gm
  • Dosage adjustment necessary in elderly and patients with impaired renal or hepatic function
  • Usual dose for injectable administration in adults and children

Interaction

  • Increased risk of kidney damage with concomitant use of nephrotoxic drugs like aminoglycosides
  • Enhanced possibility of renal toxicity with diuretics (e.g. frusemide, ethacrynic acid) and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Limited essentially to gastro-intestinal disturbances and on occasions to hypersensitivity phenomena
  • Possible skin reactions and hypersensitivity reactions
  • Rare occurrences of glossitis, heartburn, dizziness, nausea, vomiting, diarrhoea, abdominal pain, vaginitis, candida overgrowth

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk, caution advised in lactating mothers
  • Patients cautioned about operating hazardous machinery, including automobiles

Precautions & Warnings

  • Prolonged use may result in the development of superinfection due to the emergence of resistant organisms
  • Administered with care to patients hypersensitive to penicillins
  • May cause a false positive urine glucose result with certain testing solutions
  • Dosage adjustment necessary in renal impairment
  • Contains lactose, not suitable for patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption

Use in Special Populations

  • Recommended doses for patients with renal impairment not on haemodialysis based on creatinine clearance
  • Additional dosing information for patients on chronic, intermittent haemodialysis
  • Higher doses may be required for chronic or severe infections
  • Paediatric dosages should not exceed those specified for adults, regardless of infection severity

Overdose Effects

  • Non-specific symptoms such as nausea, vomiting, diarrhoea, and gastric upsets
  • Supportive treatment recommended
  • Gastric lavage may be necessary if a large amount has been ingested

Storage Conditions

  • Velogen Suspension should be freshly prepared
  • Reconstituted Suspension should be used within 7 days at room temperature or within 14 days in a refrigerator
  • Velogen Injection solutions should be used within 2 hours at room temperature
  • When stored at 5°C, solutions retain potency for 12 hours
  • Reconstituted solutions may vary in colour; potency is not affected
  • Do not use later than the date of expiry

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