Zecef 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 90.00

Medicine Details

Category Details
Generic Cephradine
Company Gaco pharmaceuticals ltd
Also available as
Zecef 500 mg capsule Zecef 125 mg pediatric drop

Indications

  • Treating infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Urinary tract infections
  • Skin and soft tissue infections
  • Susceptible microorganisms (gram-positive and gram-negative)

Pharmacology

  • Cephradine is a semisynthetic broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cross-linking process in bacterial cell wall
  • Main site of action is the cell wall of bacteria

Dosage & Administration

  • Dosage and administration for oral administration in adults
  • Dosage and administration for oral administration in children
  • Dosage and administration for injectable administration in adults
  • Dosage and administration for injectable administration in children
  • Dosage adjustment in renal impairment
  • Maximum daily dosage
  • Caution in elderly and patients with impaired renal or hepatic function

Interaction

  • Potential interaction with nephrotoxic drugs
  • Enhanced risk of kidney damage with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Gastro-intestinal disturbances
  • Hypersensitivity phenomena
  • Possible skin reactions
  • Rare effects such as glossitis, heartburn, dizziness, nausea, vomiting, etc.
  • Rare blood and lymphatic system disorders
  • Rare immune system disorders
  • Rare psychiatric disorders
  • Rare nervous system disorders
  • Rare hepatobiliary disorders
  • Rare renal and urinary disorders
  • Rare elevation in certain blood and urine tests

Pregnancy & Lactation

  • Safety not established in pregnancy
  • Excreted in breast milk
  • Caution in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Care in patients hypersensitive to penicillins
  • Potential positive Coombs' testing
  • Possible false positive urine glucose result
  • Dosage adjustment in renal impairment
  • Contains lactose

Use in Special Populations

  • Dosage recommendations for patients with renal impairment
  • Higher doses may be required for chronic or severe infections
  • Monitoring required for certain infections
  • Limitations on paediatric dosages
  • Possibility of transferring from intramuscular/intravenous to oral treatment
  • Extended therapy for persistent infections

Overdose Effects

  • Non-specific symptoms
  • Treatment is mainly supportive
  • Gastric lavage may be necessary

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Freshly prepared suspension
  • Expiry and storage conditions for suspension and injection solutions
  • Dispensing only on prescription of a registered physician

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