Zecef 125 mg/1.25 ml (Pediatric Drops)

15 ml bottle: ৳ 50.16

Medicine Details

Category Details
Generic Cephradine
Company Gaco pharmaceuticals ltd
Also available as
Zecef 500 mg capsule Zecef 125 mg suspension

Indications

  • Treats infections caused by sensitive Gram-positive and Gram-negative bacteria
  • Treats upper respiratory tract infections like sinusitis, pharyngitis, and tonsillitis
  • Treats lower respiratory tract infections like bronchitis and pneumonia
  • Treats urinary tract infections like cystitis and pyelonephritis
  • Treats skin and soft tissue infections like abscess and cellulitis
  • Susceptible microorganisms: Staphylococci, Streptococci, Escherichia coli, Klebsiella spp, Haemophilus influenza, Shigella spp, Salmonella spp
  • Treats infections caused by penicillin-sensitive and resistant strains
  • Treats infections caused by strains unaffected by penicillinase
  • Treats infections in adults and children

Pharmacology

  • Cephradine is a broad spectrum bactericidal antibiotic
  • Active against both gram-positive and gram-negative microorganisms
  • Inhibits cell wall cross-linking process
  • Causes lysis of bacteria due to external osmotic pressure

Dosage & Administration

  • For oral administration in adults and children
  • Different dosage for urinary tract infections, respiratory tract infections, and skin infections
  • Extra caution for elderly, renal impairment patients
  • For injectable administration in adults and children
  • Dosage adjustment necessary in renal impairment

Interaction

  • Risk of kidney damage when used with nephrotoxic drugs
  • Increased renal toxicity with diuretics and probenecid

Contraindications

  • Not to be used in patients with known or suspected hypersensitivity to cephalosporins

Side Effects

  • Limited to gastrointestinal disturbances and hypersensitivity phenomena
  • More likely to occur in individuals with allergy history
  • Rare side effects like glossitis, heartburn, dizziness, skin reactions, and joint pains

Pregnancy & Lactation

  • Safety in pregnancy not established
  • Excreted in breast milk
  • Caution advised in lactating mothers

Precautions & Warnings

  • Prolonged use may result in superinfection
  • Administer with care to patients hypersensitive to penicillins
  • May cause false positive urine glucose result

Use in Special Populations

  • Specific doses recommended for patients with renal impairment or on haemodialysis
  • Higher doses may be required for chronic or severe infections
  • Regular bacteriological and clinical monitoring required in chronic urinary tract infections

Overdose Effects

  • Non-specific symptoms like nausea, vomiting, and gastric upsets

Therapeutic Class

  • First generation Cephalosporins

Storage Conditions

  • Suspension should be freshly prepared
  • Reconstituted suspension should be used within 7-14 days
  • Injection solutions should be used within 2 hours when kept at room temperature
  • Solutions retain potency for 12 hours when stored at 5°C
  • Do not use after the date of expiry

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