ATV Plus 5 mg+10 mg (Tablet)

Title

• Amlodipine Besilate and Atorvastatin Calcium Tablets

Categories

• Hypertension medication
• Chronic stable angina treatment
• Hypercholesterolemia therapy
• Lipid-lowering and anti-anginal medication
• Pediatric contraindications
• Geriatric usage

Dosage

• Initial antihypertensive oral dose of Amlodipine: 5 mg once daily
• Initial Amlodipine dose for chronic stable or vasospastic angina: 5-10 mg
• Recommended starting dose of Atorvastatin: 10 mg daily
• Dosage range for Atorvastatin: 10 to 80 mg once daily
• Atorvastatin administration: can be administered as a single dose at any time of the day with or without food

Mode of Action

• Amlodipine: peripheral arterial vasodilator
• Amlodipine: reduction in peripheral vascular resistance and blood pressure
• Atorvastatin: synthetic lipid-lowering agent
• Atorvastatin: HMG-CoA reductase inhibitor

Interaction

• Drug interaction with Amlodipine: potentiation of other antihypertensive drugs' effects
• Amlodipine did not affect the pharmacokinetics of Atorvastatin, Digoxin, Warfarin, or Cyclosporine

Contraindications

• Amlodipine: known hypersensitivity to Amlodipine
• Atorvastatin: hypersensitivity to any component of this medication
• Atorvastatin: active liver disease or unexplained persistent elevations of serum transaminases exceeding three times the upper limit of normal

Side Effects

• Amlodipine-induced vasodilatation gradual in onset, caution advised for acute hypotension
• Atorvastatin may cause elevation in serum creatine phosphokinase levels
• Commonly reported Atorvastatin adverse effects: constipation, flatulence, dyspepsia, headache, nausea, myalgia, diarrhea, asthenia, insomnia

Pregnancy & Lactation

• Safety not established in pregnancy
• Use of HMG-CoA reductase inhibitors during breastfeeding not recommended

Precautions & Warnings

• Caution advised with Amlodipine in patients with severe aortic stenosis
• Amlodipine use in patients with congestive heart failure to be exercised with caution
• Atorvastatin therapy should be discontinued if markedly elevated CPK levels occur

Pediatric Uses

• Safety and efficacy of Atorvastatin not established in children

Storage Conditions

• Store in a cool and dry place
• Protect from light and moisture
• Keep all medicines out of the reach of children

Indications

• Treatment of hypertension
• Treatment of chronic stable angina
• Adjunct to diet for hypercholesterolemia
• Reduction of risk of nonfatal MI and nonfatal stroke in hypertensive patients with multiple risk factors for CHD

Pharmacology

• Amlodipine: calcium channel blocker
• Atorvastatin: statin (HMG-CoA reductase inhibitor)
• Amlodipine acts directly on vascular smooth muscle to reduce peripheral vascular resistance
• Atorvastatin inhibits the conversion of HMG-CoA to mevatonate, a rate limiting step in the synthesis of cholesterol

Therapeutic Class

• Anti-anginal drugs
• Lipid-lowering medications

Warnings

• Increased frequency, duration, and/or severity of angina or acute myocardial infarction documented in rare cases on starting calcium channel blocker therapy
• Liver dysfunction associated with HMG-CoA reductase inhibitors

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